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Chemokine and Free Fatty Acid Levels in Insulin-Resistant State of Successful Pregnancy: A Preliminary Observation
Joint Authors
Noguchi, Taketoshi
Naruse, Katsuhiko
Shigetomi, Hiroshi
Kobayashi, Hiroshi
Tsunemi, Taihei
Kanayama, Seiji
Akasaka, Juria
Koike, Natsuki
Oi, Hidekazu
Sado, Toshiyuki
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Increased insulin resistance and inflammatory action are observed in pregnancy-induced hypertension (PIH), but similar insulin resistance is observed also in successful pregnancy.
To estimate insulin resistance and inflammatory activity in normal pregnancy and PIH, serum concentrations of free fatty acids (FFA; corrected with albumin to estimate unbound FFA), monocyte chemoattractant protein (MCP)-1, and high-molecular weight (HMW) adiponectin were measured in severe PIH patients with a BMI less than 25 kg/m2 and were measured 3 times during the course of pregnancy in women with normal pregnancies.
FFA/albumin, MCP-1, and HMW adiponectin concentrations were significantly higher in PIH patients than in women with normal pregnancies.
The 3 measurements of FFA/albumin showed a significant increase through the course of uncomplicated pregnancies.
In contrast, MCP-1 and HMW adiponectin were significantly decreased during the course of pregnancy.
These results suggest that the reduced MCP-1 concentration in normal pregnancy may be a pathway to inhibit the induction of pathological features from physiological insulin resistance and homeostatic inflammation.
American Psychological Association (APA)
Naruse, Katsuhiko& Noguchi, Taketoshi& Sado, Toshiyuki& Tsunemi, Taihei& Shigetomi, Hiroshi& Kanayama, Seiji…[et al.]. 2012. Chemokine and Free Fatty Acid Levels in Insulin-Resistant State of Successful Pregnancy: A Preliminary Observation. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1029401
Modern Language Association (MLA)
Naruse, Katsuhiko…[et al.]. Chemokine and Free Fatty Acid Levels in Insulin-Resistant State of Successful Pregnancy: A Preliminary Observation. Mediators of Inflammation No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1029401
American Medical Association (AMA)
Naruse, Katsuhiko& Noguchi, Taketoshi& Sado, Toshiyuki& Tsunemi, Taihei& Shigetomi, Hiroshi& Kanayama, Seiji…[et al.]. Chemokine and Free Fatty Acid Levels in Insulin-Resistant State of Successful Pregnancy: A Preliminary Observation. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1029401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029401