Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period
Joint Authors
Brumann, M.
Kusmenkov, T.
Ney, L.
Kanz, K.-G.
Biberthaler, P.
Mutschler, W.
Bogner, V.
Leidel, B. A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Metalloproteinases are secreted in response to a variety of inflammatory mediators and inhibited by tissue inhibitors of matrixmetalloproteinases (TIMPs).
Two members of these families, MMP-9 and TIMP-1, were differentially expressed depending on clinical parameters in a previous genomewide mRNA analysis.
The aim of this paper was now to evaluate the posttraumatic serum levels and the time course of both proteins depending on distinct clinical parameters.
60 multiple traumatized patients (ISS > 16) were included.
Blood samples were drawn on admission and 6 h, 12 h, 24 h, 48 h, and 72 h after trauma.
Serum levels were quantified by ELISA.
MMP-9 levels significantly decreased in the early posttraumatic period (P<0.05) whereas TIMP-1 levels significantly increased in all patients (P<0.05).
MMP-9 and TIMP-1 serum concentration kinetics became manifest in an inversely proportional balance.
Furthermore, MMP-9 presented a stronger decrease in patients with severe trauma and non-survivors in contrast to minor traumatized patients (ISS ≤ 33) and survivors, initially after trauma.
American Psychological Association (APA)
Brumann, M.& Kusmenkov, T.& Ney, L.& Kanz, K.-G.& Leidel, B. A.& Biberthaler, P.…[et al.]. 2012. Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029402
Modern Language Association (MLA)
Brumann, M.…[et al.]. Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period. Mediators of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1029402
American Medical Association (AMA)
Brumann, M.& Kusmenkov, T.& Ney, L.& Kanz, K.-G.& Leidel, B. A.& Biberthaler, P.…[et al.]. Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029402