Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators
Joint Authors
Murrell, George A. C.
Millar, Neal L.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Tendon disorders—tendinopathies—are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations.
Whilst the molecular pathophysiology of tendinopathy remains difficult to interpret the disease process involving repetitive stress, and cellular load provides important mechanistic insight into the area of heat shock proteins which spans many disease processes in the autoimmune community.
Heat shock proteins, also called damage-associated molecular patterns (DAMPs), are rapidly released following nonprogrammed cell death, are key effectors of the innate immune system, and critically restore homeostasis by promoting the reconstruction of the effected tissue.
Our investigations have highlighted a key role for HSPs in tendion disease which may ultimately affect tissue rescue mechanisms in tendon pathology.
This paper aims to provide an overview of the biology of heat shock proteins in soft tissue and how these mediators may be important regulators of inflammatory mediators and matrix regulation in tendinopathy.
American Psychological Association (APA)
Millar, Neal L.& Murrell, George A. C.. 2012. Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029403
Modern Language Association (MLA)
Millar, Neal L.& Murrell, George A. C.. Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1029403
American Medical Association (AMA)
Millar, Neal L.& Murrell, George A. C.. Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029403