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Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders
Joint Authors
Buttari, Brigitta
Scrivo, Rossana
Masella, Roberta
Filesi, Carmelina
Tosti, Maria Elena
Scarno, Antongiulio
Spadaro, Antonio
Riganò, Rachele
Di Franco, Manuela
Profumo, Elisabetta
Saso, Luciano
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Atherosclerosis is accelerated in rheumatoid arthritis (RA) and psoriatic arthritis (PsA).
We investigated a possible association of oxidized low-density lipoproteins (ox-LDLs), nitric oxide (NO), 3-nitrotyrosine, vitamin A, vitamin E, and β-carotene serum levels with subclinical atherosclerosis in RA and PsA.
By the use of ELISA, we observed higher ox-LDL levels in patients with intima-media thickness (IMT) > 1 than in patients with IMT ≤ 1 and a negative correlation between NO levels and IMT values.
By the use of high-performance liquid chromatography, we determined higher levels of vitamin A in patients with PsA and IMT ≤ 1 than in controls and lower levels of β-carotene in patients with RA and PsA than in controls.
β-carotene concentrations were negatively correlated to the duration of disease in RA.
Our study confirms that ox-LDLs and NO may be markers of accelerated atherosclerosis in RA and PsA whereas vitamins seem to be associated only to the presence of the autoimmune disorders.
American Psychological Association (APA)
Profumo, Elisabetta& Di Franco, Manuela& Buttari, Brigitta& Masella, Roberta& Filesi, Carmelina& Tosti, Maria Elena…[et al.]. 2012. Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029408
Modern Language Association (MLA)
Profumo, Elisabetta…[et al.]. Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders. Mediators of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1029408
American Medical Association (AMA)
Profumo, Elisabetta& Di Franco, Manuela& Buttari, Brigitta& Masella, Roberta& Filesi, Carmelina& Tosti, Maria Elena…[et al.]. Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029408