Clarithromycin Suppresses Human Respiratory Syncytial VirusInfection-Induced Streptococcus pneumoniae Adhesion and CytokineProduction in a Pulmonary Epithelial Cell Line
Joint Authors
Fujii, Nobuhiro
Yokota, Shin-ichi
Okabayashi, Tamaki
Hirakawa, Satoshi
Tsutsumi, Hiroyuki
Himi, Tetsuo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Human respiratory syncytial virus (RSV) sometimes causes acute and severe lower respiratory tract illness in infants and young children.
RSV strongly upregulates proinflammatory cytokines and the platelet-activating factor (PAF) receptor, which is a receptor for Streptococcus pneumoniae, in the pulmonary epithelial cell line A549.
Clarithromycin (CAM), which is an antimicrobial agent and is also known as an immunomodulator, significantly suppressed RSV-induced production of interleukin-6, interleukin-8, and regulated on activation, normal T-cell expressed and secreted (RANTES).
CAM also suppressed RSV-induced PAF receptor expression and adhesion of fluorescein-labeled S.
pneumoniae cells to A549 cells.
The RSV-induced S.
pneumoniae adhesion was thought to be mediated by the host cell’s PAF receptor.
CAM, which exhibits antimicrobial and immunomodulatory activities, was found in this study to suppress the RSV-induced adhesion of respiratory disease-causing bacteria, S.
pneumoniae, to host cells.
Thus, CAM might suppress immunological disorders and prevent secondary bacterial infections during RSV infection.
American Psychological Association (APA)
Yokota, Shin-ichi& Okabayashi, Tamaki& Hirakawa, Satoshi& Tsutsumi, Hiroyuki& Himi, Tetsuo& Fujii, Nobuhiro. 2012. Clarithromycin Suppresses Human Respiratory Syncytial VirusInfection-Induced Streptococcus pneumoniae Adhesion and CytokineProduction in a Pulmonary Epithelial Cell Line. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029413
Modern Language Association (MLA)
Yokota, Shin-ichi…[et al.]. Clarithromycin Suppresses Human Respiratory Syncytial VirusInfection-Induced Streptococcus pneumoniae Adhesion and CytokineProduction in a Pulmonary Epithelial Cell Line. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1029413
American Medical Association (AMA)
Yokota, Shin-ichi& Okabayashi, Tamaki& Hirakawa, Satoshi& Tsutsumi, Hiroyuki& Himi, Tetsuo& Fujii, Nobuhiro. Clarithromycin Suppresses Human Respiratory Syncytial VirusInfection-Induced Streptococcus pneumoniae Adhesion and CytokineProduction in a Pulmonary Epithelial Cell Line. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029413