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Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics
Joint Authors
Theron, Annette J.
Anderson, Ronald
Feldman, Charles
Steel, Helen C.
Cockeran, Riana
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-21
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Macrolide antibiotics possess several, beneficial, secondary properties which complement their primary antimicrobial activity.
In addition to high levels of tissue penetration, which may counteract seemingly macrolide-resistant bacterial pathogens, these agents also possess anti-inflammatory properties, unrelated to their primary antimicrobial activity.
Macrolides target cells of both the innate and adaptive immune systems, as well as structural cells, and are beneficial in controlling harmful inflammatory responses during acute and chronic bacterial infection.
These secondary anti-inflammatory activities of macrolides appear to be particularly effective in attenuating neutrophil-mediated inflammation.
This, in turn, may contribute to the usefulness of these agents in the treatment of acute and chronic inflammatory disorders of both microbial and nonmicrobial origin, predominantly of the airways.
This paper is focused on the various mechanisms of macrolide-mediated anti-inflammatory activity which target both microbial pathogens and the cells of the innate and adaptive immune systems, with emphasis on their clinical relevance.
American Psychological Association (APA)
Steel, Helen C.& Theron, Annette J.& Cockeran, Riana& Anderson, Ronald& Feldman, Charles. 2012. Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-1029418
Modern Language Association (MLA)
Steel, Helen C.…[et al.]. Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics. Mediators of Inflammation No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-1029418
American Medical Association (AMA)
Steel, Helen C.& Theron, Annette J.& Cockeran, Riana& Anderson, Ronald& Feldman, Charles. Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-1029418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029418