Role of Leukotrienes on Protozoan and Helminth Infections
Joint Authors
Anibal, Fernanda F.
de Paula Rogerio, Alexandre
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities.
Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated with increased mortality and impaired clearance of bacteria, fungi, and parasites.
LTs play a role in the control of helminth and protozoan infections by modulating the immune system and/or through direct cytotoxicity to parasites; however, LTs may also be associated with pathogenesis, such as in cerebral malaria and schistosomal granuloma.
Interestingly, some proteins from the saliva of insect vectors that transmit protozoans and secreted protein from helminth could bind LTs and may consequently modulate the course of infection or pathogenesis.
In addition, the decreased production of LTs in immunocompromised individuals might modulate the pathophysiology of helminth and protozoan infections.
Herein, in this paper, we showed the immunomodulatory and pathogenic roles of LTs during the helminth and protozoan infections.
American Psychological Association (APA)
de Paula Rogerio, Alexandre& Anibal, Fernanda F.. 2012. Role of Leukotrienes on Protozoan and Helminth Infections. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1029419
Modern Language Association (MLA)
de Paula Rogerio, Alexandre& Anibal, Fernanda F.. Role of Leukotrienes on Protozoan and Helminth Infections. Mediators of Inflammation No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1029419
American Medical Association (AMA)
de Paula Rogerio, Alexandre& Anibal, Fernanda F.. Role of Leukotrienes on Protozoan and Helminth Infections. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1029419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029419