![](/images/graphics-bg.png)
Interplay between Human Cytomegalovirus and IntrinsicInnate Host Responses: A Complex Bidirectional Relationship
Joint Authors
Rossini, Giada
Cerboni, Cristina
Santoni, Angela
Landolfo, Santo
Gatti, Deborah
Gribaudo, Giorgio
Varani, Stefania
Landini, Maria Paola
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-31
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The interaction between human cytomegalovirus (HCMV) and its host is a complex process that begins with viral attachment and entry into host cells, culminating in the development of a specific adaptive response that clears the acute infection but fails to eradicate HCMV.
We review the viral and cellular partners that mediate early host responses to HCMV with regard to the interaction between structural components of virions (viral glycoproteins) and cellular receptors (attachment/entry receptors, toll-like receptors, and other nucleic acid sensors) or intrinsic factors (PML, hDaxx, Sp100, viperin, interferon inducible protein 16), the reactions of innate immune cells (antigen presenting cells and natural killer cells), the numerous mechanisms of viral immunoevasion, and the potential exploitation of events that are associated with early phases of virus-host interplay as a therapeutic strategy.
American Psychological Association (APA)
Rossini, Giada& Cerboni, Cristina& Santoni, Angela& Landini, Maria Paola& Landolfo, Santo& Gatti, Deborah…[et al.]. 2012. Interplay between Human Cytomegalovirus and IntrinsicInnate Host Responses: A Complex Bidirectional Relationship. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-1029422
Modern Language Association (MLA)
Rossini, Giada…[et al.]. Interplay between Human Cytomegalovirus and IntrinsicInnate Host Responses: A Complex Bidirectional Relationship. Mediators of Inflammation No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-1029422
American Medical Association (AMA)
Rossini, Giada& Cerboni, Cristina& Santoni, Angela& Landini, Maria Paola& Landolfo, Santo& Gatti, Deborah…[et al.]. Interplay between Human Cytomegalovirus and IntrinsicInnate Host Responses: A Complex Bidirectional Relationship. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-1029422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029422