Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils
Joint Authors
Suchankova, Magda
Dzurilla, Martin
Vrlik, Mojmir
Novosadova, Helena
Tedlova, Eva
Urban, Stefan
Hornakova, Edita
Seligova, Marianna
Durmanova, Vladimira
Penz, Peter
Javor, Juraj
Paulovicova, Ema
Bucova, Maria
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The knowledge that asthma is an inflammatory disorder has prompted us to investigate the plasma levels of a new inflammatory marker sTREM-1 that is released from the surfaces of activated neutrophils and monocytes.
The plasma levels of sTREM-1 were analysed by a sandwich ELISA test in the cohort of 76 patients with allergic asthma bronchiale and 39 healthy controls.
Our results revealed more than 3.5 times higher levels of sTREM-1 in AB patients (92.3 pg/mL ± 125.6) compared with healthy subjects (25.7 pg/mL ± 9.2; P=0.0001).
Higher levels of sTREM-1 were found also in patients with exacerbated AB (170.5 pg/mL ± 78.2) compared with nonexacerbated AB patients (59.1 ± 78.2; P<0.0001), patients with respiratory tract obstruction (176.4 pg/mL ± 177.8), than those without obstruction (51.99 pg/mL ± 64.0; P<0.0001) and patients with anti-IgE therapy (P<0.0001).
Levels of sTREM-1 correlated with number of leucocytes (P=0.002), and absolute number of neutrophils (P=0.001).
Elevated plasma levels of sTREM-1 reflect the severity, state of exacerbation, presence of respiratory tract obstruction in AB patients and together with increased number of neutrophils point to the role of neutrophils in inflammation accompanying AB.
American Psychological Association (APA)
Bucova, Maria& Suchankova, Magda& Dzurilla, Martin& Vrlik, Mojmir& Novosadova, Helena& Tedlova, Eva…[et al.]. 2012. Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029425
Modern Language Association (MLA)
Bucova, Maria…[et al.]. Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils. Mediators of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1029425
American Medical Association (AMA)
Bucova, Maria& Suchankova, Magda& Dzurilla, Martin& Vrlik, Mojmir& Novosadova, Helena& Tedlova, Eva…[et al.]. Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029425