Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice
Joint Authors
Esposito, Emanuela
Cuzzocrea, Salvatore
Elena, Talero
Virginia, Motilva
Mazzon, Emanuela
Di Paola, Rosanna
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Adrenomedullin (AM) is a 52 amino acid peptide that has shown predominant anti-inflammatory activities.
In the present study, we evaluated the possible therapeutic effect of this peptide in an experimental model of acute inflammation, the carrageenan- (CAR-) induced pleurisy.
Pleurisy was induced by injection of CAR into the pleural cavity of mice.
AM (200 ng/kg) was administered by intraperitoneal route 1 h after CAR, and the animals were sacrificed 4 h after that.
AM treatment attenuated the recruitment of leucocytes in the lung tissue and the generation and/or the expression of the proinflammatory cytokines as well as the expression of the intercellular cell adhesion molecules.
Moreover, AM inhibited the induction of inducible nitric oxide synthase (iNOS), thereby abating the generation of nitric oxide (NO) and prevented the oxidative and nitroxidative lung tissue injury, as shown by the reduction of nitrotyrosine, malondialdehyde (MDA), and poly (ADP-ribose) polymerase (PARP) levels.
Finally, we demonstrated that these anti-inflammatory effects of AM were associated with the inhibition of nuclear factor-κB (NF-κB) activation.
All these parameters were markedly increased by intrapleural CAR in the absence of any treatment.
We report that treatment with AM significantly reduces the development of acute lung injury by downregulating a broad spectrum of inflammatory factors.
American Psychological Association (APA)
Elena, Talero& Di Paola, Rosanna& Mazzon, Emanuela& Esposito, Emanuela& Virginia, Motilva& Cuzzocrea, Salvatore. 2012. Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1029431
Modern Language Association (MLA)
Elena, Talero…[et al.]. Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice. Mediators of Inflammation No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1029431
American Medical Association (AMA)
Elena, Talero& Di Paola, Rosanna& Mazzon, Emanuela& Esposito, Emanuela& Virginia, Motilva& Cuzzocrea, Salvatore. Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1029431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029431