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Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst
Joint Authors
Kelkka, Tiina
Laurila, Juha Petteri
Sareila, Outi
Olofsson, Peter
Laukkanen, Mikko Olavi
Holmdahl, Rikard
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Extracellular superoxide dismutase (SOD3), an enzyme mediating dismutation of superoxide into hydrogen peroxide, has been shown to reduce inflammation by inhibiting macrophage migration into injured tissues.
In inflamed tissues, superoxide is produced by the phagocytic NOX2 complex, which consists of the catalytic subunit NOX2 and several regulatory subunits (e.g., NCF1).
To analyze whether SOD3 can regulate inflammation in the absence of functional NOX2 complex, we injected an adenoviral vector overexpressing SOD3 directly into the arthritic paws of Ncf1*/* mice with collagen-induced arthritis.
SOD3 reduced arthritis severity in both oxidative burst-deficient Ncf1*/* mice and also in wild-type mice.
The NOX2 complex independent anti-inflammatory effect of SOD3 was further characterized in peritonitis, and SOD3 was found to reduce macrophage infiltration independently of NOX2 complex functionality.
We conclude that the SOD3-mediated anti-inflammatory effect on arthritis and peritonitis operates independently of NOX2 complex derived oxidative burst.
American Psychological Association (APA)
Kelkka, Tiina& Laurila, Juha Petteri& Sareila, Outi& Olofsson, Peter& Laukkanen, Mikko Olavi& Holmdahl, Rikard. 2012. Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029433
Modern Language Association (MLA)
Kelkka, Tiina…[et al.]. Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1029433
American Medical Association (AMA)
Kelkka, Tiina& Laurila, Juha Petteri& Sareila, Outi& Olofsson, Peter& Laukkanen, Mikko Olavi& Holmdahl, Rikard. Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029433