Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients
Joint Authors
Zheng, Yanhua
Huang, Zemin
Chen, Xianhua
Tang, Jun
Zhang, Yi
Zhang, Xiaomin
Zhou, Jijun
Wang, Qinghong
Ni, Bing
Mao, Qing
Wu, Yu-Zhang
Tian, Yi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
CD4+ T cells serve as master regulators of the adaptive immune response to HBV.
However, CD4+ T-cell subsets are heterogeneous, and it remains unknown how the antiviral agents affect the different CD4+ T cell subtypes.
To this end, the expressions of signature transcription factors and cytokines of CD4+ T-cell subtypes were examined in hepatitis B patients before and after treatment with telbivudine.
Results showed that, upon the rapid HBV copy decrease induced by telbivudine treatment, the frequencies and related cytokines of Th17 and Treg cells were dramatically decreased, while those for Th2 cells were dramatically increased.
No obvious changes were observed in Th1 cell frequencies; although, IFN-γ expression was upregulated in response to telbivudine treatment, suggesting another cell source of IFN-γ in CHB patients.
Statistical analyses indicated that Th17 and Tr1 (a Treg subtype) cells were the most sensitive subpopulations of the peripheral blood CD4+ T cells to telbivudine treatment over 52 weeks.
Thus, Th17 and Tr1 cells may represent a suitable and effective predictor of responsiveness during telbivudine therapy.
These findings not only improve our understanding of hepatitis pathogenesis but also can aid in future development of appropriate therapeutic strategies to control viral hepatitis.
American Psychological Association (APA)
Zheng, Yanhua& Huang, Zemin& Chen, Xianhua& Tian, Yi& Tang, Jun& Zhang, Yi…[et al.]. 2012. Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029441
Modern Language Association (MLA)
Zheng, Yanhua…[et al.]. Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1029441
American Medical Association (AMA)
Zheng, Yanhua& Huang, Zemin& Chen, Xianhua& Tian, Yi& Tang, Jun& Zhang, Yi…[et al.]. Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029441