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Pegylated Arginine Deiminase Downregulates Colitis in Murine Models
Joint Authors
Zhong, Jian
de Villiers, Willem J. S.
Oz, Helieh S.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Arginine deiminase (ADI), an arginine-metabolizing enzyme involved in cell signaling, is dysregulated in multiple inflammatory diseases and cancers.
We hypothesized that pegylated ADI (ADI-PEG) provide protection against colitis.
Methods.
Dextran sodium sulfate colitis was induced in IL-10-deficient and BALB/c (WT) mice.
ADI-PEG was administered i.p., and inflammatory mediators and pathology were evaluated.
Results.
Acute colitis in mice was manifested by increases in inflammatory biomarkers, such as serum amyloid A (SAA, P<0.001), IL-12 p40, and disease index (3-Fold).
In contrast, ADI-PEG significantly decreased clinical disease index, SAA levels, and inflammatory cytokines in blood as well as in colonic explants.
Animals developed moderate (2.2±0.3 WT) to severe (3.6±0.5 IL-10 deficient) colonic pathology; and ADI-PEG treatment significantly improved the severity of colitis (P<0.05).
Marked infiltration of CD68+ macrophages and iNOS expression were detected in colonic submucosa in colitic animals but not detected in ADI-PEG-treated animals.
Conclusion.
ADI-PEG attenuated inflammatory responses by suppression of macrophage infiltration and iNOS expression in colitic animals.
ADI-PEG can serve as a potential therapeutic value in IBD.
American Psychological Association (APA)
Oz, Helieh S.& Zhong, Jian& de Villiers, Willem J. S.. 2011. Pegylated Arginine Deiminase Downregulates Colitis in Murine Models. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029444
Modern Language Association (MLA)
Oz, Helieh S.…[et al.]. Pegylated Arginine Deiminase Downregulates Colitis in Murine Models. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1029444
American Medical Association (AMA)
Oz, Helieh S.& Zhong, Jian& de Villiers, Willem J. S.. Pegylated Arginine Deiminase Downregulates Colitis in Murine Models. Mediators of Inflammation. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029444