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Association between Polymorphisms in Interleukin-17A and -17F Genes and Chronic Periodontal Disease
Joint Authors
Silva, Tarcília Aparecida da
Queiroz-Junior, Celso Martins
Resende, Renata Gonçalves
Correia-Silva, Jeane de Fátima
Souza, Danielle da Glória de
Teixeira, Mauro Martins
Madeira, Mila Fernandes Moreira
Gomez, Ricardo Santiago
Corrêa, Jôice Dias
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Interleukin-17 (IL-17) is a cytokine that induces neutrophil recruitment and the release of inflammatory mediators in several inflammatory conditions; nevertheless, the involvement of IL-17 gene polymorphisms in chronic periodontitis (CP) has not been addressed yet.
Our aim was to evaluate the association between periodontal status and the polymorphisms IL-17A G197A and IL-17F C7488T in subjects with CP along with their impact on levels of inflammatory mediators.
Material and Methods.
Genomic DNA was obtained from 30 CP patients and 30 healthy controls (HCs).
IL-17A G197A and IL-17F C7488T polymorphisms were determined using PCR-RFLP.
Serum and periodontal tissues were collected and processed for ELISA, myeloperoxidase (MPO), and/or microscopic analysis.
Results.
The frequencies of genotypes in the CP group were significantly different from those of HC.
Odds ratio indicated that increased risks for CP were associated with the -197A allele, not with the -7488T allele.
In addition, the -197A allele was correlated with worse clinical parameters, higher MPO activity, and increased expression of inflammatory mediators (IL-17A and IL-8) than the other genotypes.
Conclusions.
These results indicate that the IL-17A -197A allele is associated with increased risk for CP, likely because this genotype relates to the enhanced inflammation in periodontal tissues.
American Psychological Association (APA)
Corrêa, Jôice Dias& Madeira, Mila Fernandes Moreira& Resende, Renata Gonçalves& Correia-Silva, Jeane de Fátima& Gomez, Ricardo Santiago& Souza, Danielle da Glória de…[et al.]. 2012. Association between Polymorphisms in Interleukin-17A and -17F Genes and Chronic Periodontal Disease. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029449
Modern Language Association (MLA)
Corrêa, Jôice Dias…[et al.]. Association between Polymorphisms in Interleukin-17A and -17F Genes and Chronic Periodontal Disease. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1029449
American Medical Association (AMA)
Corrêa, Jôice Dias& Madeira, Mila Fernandes Moreira& Resende, Renata Gonçalves& Correia-Silva, Jeane de Fátima& Gomez, Ricardo Santiago& Souza, Danielle da Glória de…[et al.]. Association between Polymorphisms in Interleukin-17A and -17F Genes and Chronic Periodontal Disease. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029449