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IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels
Joint Authors
Castrén, Eero
Maya-Vetencourt, José Fernando
Baroncelli, Laura
Viegi, Alessandro
Tiraboschi, Ettore
Cattaneo, Antonino
Maffei, Lamberto
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The central nervous system architecture is markedly modified by sensory experience during early life, but a decline of plasticity occurs with age.
Recent studies have challenged this dogma providing evidence that both pharmacological treatments and paradigms based on the manipulation of environmental stimulation levels can be successfully employed as strategies for enhancing plasticity in the adult nervous system.
Insulin-like growth factor 1 (IGF-1) is a peptide implicated in prenatal and postnatal phases of brain development such as neurogenesis, neuronal differentiation, synaptogenesis, and experience-dependent plasticity.
Here, using the visual system as a paradigmatic model, we report that IGF-1 reactivates neural plasticity in the adult brain.
Exogenous administration of IGF-1 in the adult visual cortex, indeed, restores the susceptibility of cortical neurons to monocular deprivation and promotes the recovery of normal visual functions in adult amblyopic animals.
These effects were accompanied by a marked reduction of intracortical GABA levels.
Moreover, we show that a transitory increase of IGF-1 expression is associated to the plasticity reinstatement induced by environmental enrichment (EE) and that blocking IGF-1 action by means of the IGF-1 receptor antagonist JB1 prevents EE effects on plasticity processes.
American Psychological Association (APA)
Maya-Vetencourt, José Fernando& Baroncelli, Laura& Viegi, Alessandro& Tiraboschi, Ettore& Castrén, Eero& Cattaneo, Antonino…[et al.]. 2012. IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels. Neural Plasticity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029892
Modern Language Association (MLA)
Maya-Vetencourt, José Fernando…[et al.]. IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels. Neural Plasticity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1029892
American Medical Association (AMA)
Maya-Vetencourt, José Fernando& Baroncelli, Laura& Viegi, Alessandro& Tiraboschi, Ettore& Castrén, Eero& Cattaneo, Antonino…[et al.]. IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029892