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Induced Pluripotent Stem Cells to Model and Treat Neurogenetic Disorders
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Remarkable advances in cellular reprogramming have made it possible to generate pluripotent stem cells from somatic cells, such as fibroblasts obtained from human skin biopsies.
As a result, human diseases can now be investigated in relevant cell populations derived from induced pluripotent stem cells (iPSCs) of patients.
The rapid growth of iPSC technology has turned these cells into multipurpose basic and clinical research tools.
In this paper, we highlight the roles of iPSC technology that are helping us to understand and potentially treat neurological diseases.
Recent studies using iPSCs to model various neurogenetic disorders are summarized, and we discuss the therapeutic implications of iPSCs, including drug screening and cell therapy for neurogenetic disorders.
Although iPSCs have been used in animal models with promising results to treat neurogenetic disorders, there are still many issues associated with reprogramming that must be addressed before iPSC technology can be fully exploited with translation to the clinic.
American Psychological Association (APA)
Wang, Hansen& Doering, Laurie. 2012. Induced Pluripotent Stem Cells to Model and Treat Neurogenetic Disorders. Neural Plasticity،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1029908
Modern Language Association (MLA)
Wang, Hansen& Doering, Laurie. Induced Pluripotent Stem Cells to Model and Treat Neurogenetic Disorders. Neural Plasticity No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1029908
American Medical Association (AMA)
Wang, Hansen& Doering, Laurie. Induced Pluripotent Stem Cells to Model and Treat Neurogenetic Disorders. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1029908
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029908