Widespread Structural and Functional Connectivity Changes in Amyotrophic Lateral Sclerosis: Insights from Advanced Neuroimaging Research
Joint Authors
Monsurrò, Maria Rosaria
Trojsi, Francesca
Esposito, Fabrizio
Tedeschi, Gioacchino
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease principally affecting motor neurons.
Besides motor symptoms, a subset of patients develop cognitive disturbances or even frontotemporal dementia (FTD), indicating that ALS may also involve extramotor brain regions.
Both neuropathological and neuroimaging findings have provided further insight on the widespread effect of the neurodegeneration on brain connectivity and the underlying neurobiology of motor neurons degeneration.
However, associated effects on motor and extramotor brain networks are largely unknown.
Particularly, neuropathological findings suggest that ALS not only affects the frontotemporal network but rather is part of a wide clinicopathological spectrum of brain disorders known as TAR-DNA binding protein 43 (TDP-43) proteinopathies.
This paper reviews the current state of knowledge concerning the neuropsychological and neuropathological sequelae of TDP-43 proteinopathies, with special focus on the neuroimaging findings associated with cognitive change in ALS.
American Psychological Association (APA)
Trojsi, Francesca& Monsurrò, Maria Rosaria& Esposito, Fabrizio& Tedeschi, Gioacchino. 2012. Widespread Structural and Functional Connectivity Changes in Amyotrophic Lateral Sclerosis: Insights from Advanced Neuroimaging Research. Neural Plasticity،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1029917
Modern Language Association (MLA)
Trojsi, Francesca…[et al.]. Widespread Structural and Functional Connectivity Changes in Amyotrophic Lateral Sclerosis: Insights from Advanced Neuroimaging Research. Neural Plasticity No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1029917
American Medical Association (AMA)
Trojsi, Francesca& Monsurrò, Maria Rosaria& Esposito, Fabrizio& Tedeschi, Gioacchino. Widespread Structural and Functional Connectivity Changes in Amyotrophic Lateral Sclerosis: Insights from Advanced Neuroimaging Research. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1029917
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029917