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Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity
Joint Authors
Allyson, Julie
Baudry, Michel
Bi, Xiaoning
Massicotte, Guy
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Phospholipases A2 (PLA2s) represent one of the largest groups of lipid-modifying enzymes.
Over the years, significant advances have been made in understanding their potential physiological and pathological functions.
Depending on their calcium requirement for activation, PLA2s are classified into calcium dependent and independent.
This paper mainly focuses on brain calcium-independent PLA2 (iPLA2) and on the mechanisms by which they influence neuronal function and regulate synaptic plasticity.
Particular attention will be given to the iPLA2γ isoform and its role in the regulation of synaptic glutamate receptors.
In particular, the paper discusses the possibility that brain iPLA2γ deficiencies could destabilise normal synaptic operation and might contribute to the aetiology of some brain disorders.
In this line, the paper presents new data indicating that iPLA2γ deficiencies accentuate AMPA receptor destabilization and tau phosphorylation, which suggests that this iPLA2 isoform should be considered as a potential target for the treatment of Tau-related disorders.
American Psychological Association (APA)
Allyson, Julie& Bi, Xiaoning& Baudry, Michel& Massicotte, Guy. 2012. Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity. Neural Plasticity،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1029919
Modern Language Association (MLA)
Allyson, Julie…[et al.]. Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity. Neural Plasticity No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1029919
American Medical Association (AMA)
Allyson, Julie& Bi, Xiaoning& Baudry, Michel& Massicotte, Guy. Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1029919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029919