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Visual Cortex Plasticity: A Complex Interplay of Genetic and Environmental Influences
Joint Authors
Maya-Vetencourt, José Fernando
Origlia, Nicola
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The central nervous system architecture is highly dynamic and continuously modified by sensory experience through processes of neuronal plasticity.
Plasticity is achieved by a complex interplay of environmental influences and physiological mechanisms that ultimately activate intracellular signal transduction pathways regulating gene expression.
In addition to the remarkable variety of transcription factors and their combinatorial interaction at specific gene promoters, epigenetic mechanisms that regulate transcription have emerged as conserved processes by which the nervous system accomplishes the induction of plasticity.
Experience-dependent changes of DNA methylation patterns and histone posttranslational modifications are, in fact, recruited as targets of plasticity-associated signal transduction mechanisms.
Here, we shall concentrate on structural and functional consequences of early sensory deprivation in the visual system and discuss how intracellular signal transduction pathways associated with experience regulate changes of chromatin structure and gene expression patterns that underlie these plastic phenomena.
Recent experimental evidence for mechanisms of cross-modal plasticity following congenital or acquired sensory deprivation both in human and animal models will be considered as well.
We shall also review different experimental strategies that can be used to achieve the recovery of sensory functions after long-term deprivation in humans.
American Psychological Association (APA)
Maya-Vetencourt, José Fernando& Origlia, Nicola. 2012. Visual Cortex Plasticity: A Complex Interplay of Genetic and Environmental Influences. Neural Plasticity،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1029923
Modern Language Association (MLA)
Maya-Vetencourt, José Fernando& Origlia, Nicola. Visual Cortex Plasticity: A Complex Interplay of Genetic and Environmental Influences. Neural Plasticity No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1029923
American Medical Association (AMA)
Maya-Vetencourt, José Fernando& Origlia, Nicola. Visual Cortex Plasticity: A Complex Interplay of Genetic and Environmental Influences. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1029923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029923