Interobserver Agreement for Endometrial Cancer Characteristics Evaluated on Biopsy Material
Joint Authors
Ismiil, N.
Dubé, V.
Ghorab, Z.
Grin, A.
Ackerman, I.
Khalifa, M. A.
Nofech-Mozes, Sharon
Saad, R. S.
Source
Obstetrics and Gynecology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A shift toward a disease-based therapy designed according to patterns of failure and likelihood of nodal involvement predicted by pathologic determinants has recently led to considering a selective approach to lymphadenectomy for endometrial cancer.
Therefore, it became critical to examine reproducibility of diagnosing the key determinants of risk, on preoperative endometrial tissue samples as well as the concordance between preoperative and postresection specimens.
Six gynaecologic pathologists assessed 105 consecutive endometrial biopsies originally reported as positive for endometrial cancer for cell type (endometrioid versus nonendometrioid), tumor grade (FIGO 3-tiered and 2-tiered), nuclear grade, and risk category (low risk defined as endometrioid histology, grade 1 + 2 and nuclear grade <3).
Interrater agreement levels were substantial for identification of nonendometrioid histology (κ = 0.63; SE = 0.025), high tumor grade (κ = 0.64; SE = 0.025), and risk category (κ = 0.66; SE = 0.025).
The overall agreement was fair for nuclear grade (κ = 0.21; SE = 0.025).
There is agreement amongst pathologists in identifying high-risk pathologic determinants on endometrial cancer biopsies, and these highly correlate with postresection specimens.
This is ascertainment prerequisite adaptation of the paradigm shift in surgical staging of patients with endometrial cancer.
American Psychological Association (APA)
Nofech-Mozes, Sharon& Ismiil, N.& Dubé, V.& Saad, R. S.& Ghorab, Z.& Grin, A.…[et al.]. 2012. Interobserver Agreement for Endometrial Cancer Characteristics Evaluated on Biopsy Material. Obstetrics and Gynecology International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1029961
Modern Language Association (MLA)
Nofech-Mozes, Sharon…[et al.]. Interobserver Agreement for Endometrial Cancer Characteristics Evaluated on Biopsy Material. Obstetrics and Gynecology International No. 2012 (Dec. 2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1029961
American Medical Association (AMA)
Nofech-Mozes, Sharon& Ismiil, N.& Dubé, V.& Saad, R. S.& Ghorab, Z.& Grin, A.…[et al.]. Interobserver Agreement for Endometrial Cancer Characteristics Evaluated on Biopsy Material. Obstetrics and Gynecology International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1029961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029961