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Cryopreservation of Ovarian Tissue in Pediatric Patients
Joint Authors
Fabbri, Raffaella
Venturoli, S.
Macciocca, Maria
Vicenti, R.
Lima, M.
Parazza, I.
Magnani, V.
Pasquinelli, Gianandrea
Source
Obstetrics and Gynecology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cancer treatments improve the survival rate of children and adolescents; however chemo- and radiotherapy result in gonadal damage leading to acute ovarian failure and sterility.
Ovarian tissue cryopreservation allows long-term storage of primordial follicles and represents the only possibility of preserving the potential fertility in prepubertal girls.
The aim of the present study is to describe our experience in ovarian tissue cryopreservation in 45 pediatric patients.
The number of follicles per square millimeter of the overall section area and follicle quality were evaluated histologically.
A strong negative correlation was found between age and follicular density in patients both prior to and after chemotherapy (P<0.0001).
Damage in follicular quality, that is, increased oocyte vacuolization and detachment of the oocyte from granulosa cells, was found after chemotherapy.
Ovarian tissue cryopreservation, preferably performed before initiation of chemotherapy, should be offered to pediatric patients, including prepubertal girls, at risk of sterility.
American Psychological Association (APA)
Fabbri, Raffaella& Vicenti, R.& Macciocca, Maria& Pasquinelli, Gianandrea& Lima, M.& Parazza, I.…[et al.]. 2012. Cryopreservation of Ovarian Tissue in Pediatric Patients. Obstetrics and Gynecology International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029978
Modern Language Association (MLA)
Fabbri, Raffaella…[et al.]. Cryopreservation of Ovarian Tissue in Pediatric Patients. Obstetrics and Gynecology International No. 2012 (Dec. 2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1029978
American Medical Association (AMA)
Fabbri, Raffaella& Vicenti, R.& Macciocca, Maria& Pasquinelli, Gianandrea& Lima, M.& Parazza, I.…[et al.]. Cryopreservation of Ovarian Tissue in Pediatric Patients. Obstetrics and Gynecology International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029978