![](/images/graphics-bg.png)
Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients
Joint Authors
Bhartiya, Deepa
Sriraman, Kalpana
Parte, Seema
Source
Obstetrics and Gynecology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed.
We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries and presented a model that proposes that the ovary harbors two distinct populations of stem cells, namely, pluripotent, quiescent, very small embryonic-like stem cells (VSELs), and slightly larger “progenitor” ovarian germ stem cells (OGSCs).
Besides compromising the somatic niche, oncotherapy destroys OGSCs since, like tumor cells, they are actively dividing; however VSELs persist since they are relatively quiescent.
BMT or transplanted ovarian cortical tissue may help rejuvenate the ovarian niche, which possibly supports differentiation of persisting VSELs resulting in neo-oogenesis and follicular development responsible for successful pregnancies.
Postnatal oogenesis in mammalian ovary from VSELs may be exploited for fertility restoration in cancer survivors including those who were earlier deprived of gametes and/or gonadal tissue cryopreservation options.
American Psychological Association (APA)
Bhartiya, Deepa& Sriraman, Kalpana& Parte, Seema. 2012. Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients. Obstetrics and Gynecology International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029979
Modern Language Association (MLA)
Bhartiya, Deepa…[et al.]. Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients. Obstetrics and Gynecology International No. 2012 (Dec. 2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1029979
American Medical Association (AMA)
Bhartiya, Deepa& Sriraman, Kalpana& Parte, Seema. Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients. Obstetrics and Gynecology International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029979