Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern
Joint Authors
Steen, Vidar M.
Bjerkehagen, Bodil
Bruland, Øyvind S.
Myklebost, Ola
Kresse, Stine H.
Henriksen, Jørn
Sæter, Gunnar
Namløs, Heidi M.
Müller, Christoph R.
Holdhus, Rita
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Global gene expression analysis was performed on a panel of 23 osteosarcoma samples of primary and metastatic origin using the Applied Biosystems Gene Expression Array System.
When comparing the primary tumours with the metastases, we found a significantly increased expression of genes involved in immunological processes, for example coding for cytokines and chemokines, in the metastatic samples.
In addition, a comparison of the gene expression in primary samples from patients with or without metastases demonstrated that patients who later developed metastases had high expression of the chemokine (C-X-C motif) receptor 4 (CXCR4), similar to the metastatic samples, suggesting that these signal molecules play an important role in promoting metastasis.
Increased knowledge of mechanisms and interactions between specified molecular signalling pathways in osteosarcomas could lead to a more rational strategy for development of targeted therapy.
American Psychological Association (APA)
Namløs, Heidi M.& Kresse, Stine H.& Müller, Christoph R.& Henriksen, Jørn& Holdhus, Rita& Sæter, Gunnar…[et al.]. 2012. Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern. Complexity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1029990
Modern Language Association (MLA)
Namløs, Heidi M.…[et al.]. Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern. Complexity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1029990
American Medical Association (AMA)
Namløs, Heidi M.& Kresse, Stine H.& Müller, Christoph R.& Henriksen, Jørn& Holdhus, Rita& Sæter, Gunnar…[et al.]. Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern. Complexity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1029990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029990