![](/images/graphics-bg.png)
Human Muscle Progenitor Cells Displayed Immunosuppressive Effect through Galectin-1 and Semaphorin-3A
Joint Authors
Lecourt, Séverine
Lepelletier, Yves
Vanneaux, Valérie
Jarray, Rafika
Domet, Thomas
Raynaud, Françoise
Hadj-Slimane, Réda
Cras, Audrey
Larghero, Jérôme
Marolleau, J. P.
Hermine, Olivier
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-23
Country of Publication
Egypt
No. of Pages
7
Abstract EN
In human skeletal muscle, myoblasts represent the main population of myogenic progenitors.
We previously showed that, beside their myogenic differentiation capacities, myoblasts also differentiate towards osteogenic and chondrogenic lineages, some properties generally considered being hallmarks of mesenchymal stem cells (MSCs).
MSCs are also characterized by their immunosuppressive potential, through cell-cell contacts and soluble factors, including prostaglandin E-2 (PGE-2), transforming growth factor-β1 (TGF-β1), interleukine-10, or indoleamine 2,3-dioxygenase.
We and others also reported that Galectin-1 (Gal-1) and Semaphorin-3A (Sema-3A) were involved in MSCs-mediated immunosuppression.
Here, we show that human myoblasts induce a significant and dose-dependant proliferation inhibition, independently of PGE-2 and TGF-β1.
Our experiments revealed that myoblasts, in culture or in situ in human muscles, expressed and secreted Gal-1 and Sema-3A.
Furthermore, myoblasts immunosuppressive functions were reverted by using blocking antibodies against Gal-1 or Sema-3A.
Together, these results demonstrate an unsuspected immunosuppressive effect of myoblasts that may open new therapeutic perspectives.
American Psychological Association (APA)
Lecourt, Séverine& Lepelletier, Yves& Vanneaux, Valérie& Jarray, Rafika& Domet, Thomas& Raynaud, Françoise…[et al.]. 2012. Human Muscle Progenitor Cells Displayed Immunosuppressive Effect through Galectin-1 and Semaphorin-3A. Stem Cells International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1030013
Modern Language Association (MLA)
Lecourt, Séverine…[et al.]. Human Muscle Progenitor Cells Displayed Immunosuppressive Effect through Galectin-1 and Semaphorin-3A. Stem Cells International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1030013
American Medical Association (AMA)
Lecourt, Séverine& Lepelletier, Yves& Vanneaux, Valérie& Jarray, Rafika& Domet, Thomas& Raynaud, Françoise…[et al.]. Human Muscle Progenitor Cells Displayed Immunosuppressive Effect through Galectin-1 and Semaphorin-3A. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1030013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030013