Induction Therapy and Stem Cell Mobilization in Patients with Newly Diagnosed Multiple Myeloma
Joint Authors
Solimando, Antonio Giovanni
Mangialardi, Giuseppe
Moschetta, Michele
Gelao, Lucia
Iodice, Giuseppe
Vacca, Angelo
Ria, Roberto
Reale, Antonia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-31
Country of Publication
Egypt
No. of Pages
6
Abstract EN
Autologous stem cell transplantation (ASCT) is considered the standard therapy for younger patients with newly diagnosed symptomatic multiple myeloma (MM).
The introduction into clinical practice of novel agents, such as the proteasome inhibitor bortezomib and the immunomodulatory derivatives (IMiDs) thalidomide and lenalidomide, has significantly contributed to major advances in MM therapy and prognosis.
These novel agents are incorporated into induction regimens to enhance the depth of response before ASCT and further improve post-ASCT outcomes.
Between January 2000 and November 2011, 65 patients with MM were transplanted in the Department of Biomedical Science and Clinical Oncology at the University of Bari.
According to Durie-Salmon, 60 patients had stage III of disease and 5 stage II.
Only 7 patients were in stage B (renal failure).
Induction regimens that were administered in two or more cycles were VAD (vincristine, adriamycin, and dexamethasone), Thal-Dex (thalidomide, dexamethasone), Len-Dex (lenalidomide, dexamethasone), Vel-Dex (bortezomib, dexamethasone), VTD (bortezomib, thalidomide, and dexamethasone), and PAD (bortezomib, pegylated liposomal doxorubicin, and dexamethasone).
In mobilization procedure, the patients received cyclophosphamide and granulocyte colony-stimulating factor (G-CSF).
The number of cells collected through two or more leukapheresess, response after induction, and toxicity were evaluated to define the more adequate up-front induction regimen in transplantation-eligible MM patients.
American Psychological Association (APA)
Ria, Roberto& Reale, Antonia& Solimando, Antonio Giovanni& Mangialardi, Giuseppe& Moschetta, Michele& Gelao, Lucia…[et al.]. 2012. Induction Therapy and Stem Cell Mobilization in Patients with Newly Diagnosed Multiple Myeloma. Stem Cells International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1030033
Modern Language Association (MLA)
Ria, Roberto…[et al.]. Induction Therapy and Stem Cell Mobilization in Patients with Newly Diagnosed Multiple Myeloma. Stem Cells International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1030033
American Medical Association (AMA)
Ria, Roberto& Reale, Antonia& Solimando, Antonio Giovanni& Mangialardi, Giuseppe& Moschetta, Michele& Gelao, Lucia…[et al.]. Induction Therapy and Stem Cell Mobilization in Patients with Newly Diagnosed Multiple Myeloma. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1030033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030033