Transplantation of Amniotic Membrane to the Subretinal Space in Pigs
Joint Authors
Prause, J. U.
La Cour, M.
Kiilgaard, Jens Folke
Scherfig, Erik
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
5
Abstract EN
Purpose.
To investigate the effect of transplanted amniotic membrane (AM) on subretinal wound healing.
Methods.
Nine Danish Landrace pigs had surgical removal of retinal pigment epithelium (RPE) and mechanical damage of Bruch’s membrane (BM) and served as a control group.
15 pigs additionally had AM transplanted to the subretinal space.
Results.
AM significantly reduces choroidal neovascularisation when complete coverage of the induced defect is obtained (7 pigs) (P<0.05).
In cases where AM did not cover the rupture in BM choroidal tissue covered the transplanted membrane (8 pigs).
AM is well tolerated in the subretinal space, causes only limited inflammation, and is covered with a monolayer of pigmented cells when in contact with the host RPE.
Conclusions.
AM modifies choroidal neovascularisation after BM damage and may serve as a basement membrane substitute for the RPE.
American Psychological Association (APA)
Kiilgaard, Jens Folke& Scherfig, Erik& Prause, J. U.& La Cour, M.. 2012. Transplantation of Amniotic Membrane to the Subretinal Space in Pigs. Stem Cells International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1030041
Modern Language Association (MLA)
Kiilgaard, Jens Folke…[et al.]. Transplantation of Amniotic Membrane to the Subretinal Space in Pigs. Stem Cells International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-1030041
American Medical Association (AMA)
Kiilgaard, Jens Folke& Scherfig, Erik& Prause, J. U.& La Cour, M.. Transplantation of Amniotic Membrane to the Subretinal Space in Pigs. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1030041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030041