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Photoreceptor Differentiation following Transplantation of Allogeneic Retinal Progenitor Cells to the Dystrophic Rhodopsin Pro347Leu Transgenic Pig
Joint Authors
La Cour, M.
Samuel, M. S.
Prather, R. S.
Wong, F.
Petters, R. M.
Klassen, Henry
Kiilgaard, Jens Folke
Warfvinge, Karin
Young, Michael J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-09
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Purpose.
Transplantation of stem, progenitor, or precursor cells has resulted in photoreceptor replacement and evidence of functional efficacy in rodent models of retinal degeneration.
Ongoing work has been directed toward the replication of these results in a large animal model, namely, the pig.
Methods.
Retinal progenitor cells were derived from the neural retina of GFP-transgenic pigs and transplanted to the subretinal space of rhodopsin Pro347Leu-transgenic allorecipients, in the early stage of the degeneration and the absence of immune suppression.
Results.
Results confirm the survival of allogeneic porcine RPCs without immune suppression in the setting of photoreceptor dystrophy.
The expression of multiple photoreceptor markers by grafted cells included the rod outer segment-specific marker ROM-1.
Further evidence of photoreceptor differentiation included the presence of numerous photoreceptor rosettes within GFP-positive grafts, indicative of the development of cellular polarity and self-assembly into rudiments of outer retinal tissue.
Conclusion.
Together, these data support the tolerance of RPCs as allografts and demonstrate the high level of rod photoreceptor development that can be obtained from cultured RPCs following transplantation.
Strategies for further progress in this area, together with possible functional implications, are discussed.
American Psychological Association (APA)
Klassen, Henry& Kiilgaard, Jens Folke& Warfvinge, Karin& Samuel, M. S.& Prather, R. S.& Wong, F.…[et al.]. 2012. Photoreceptor Differentiation following Transplantation of Allogeneic Retinal Progenitor Cells to the Dystrophic Rhodopsin Pro347Leu Transgenic Pig. Stem Cells International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1030054
Modern Language Association (MLA)
Klassen, Henry…[et al.]. Photoreceptor Differentiation following Transplantation of Allogeneic Retinal Progenitor Cells to the Dystrophic Rhodopsin Pro347Leu Transgenic Pig. Stem Cells International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1030054
American Medical Association (AMA)
Klassen, Henry& Kiilgaard, Jens Folke& Warfvinge, Karin& Samuel, M. S.& Prather, R. S.& Wong, F.…[et al.]. Photoreceptor Differentiation following Transplantation of Allogeneic Retinal Progenitor Cells to the Dystrophic Rhodopsin Pro347Leu Transgenic Pig. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1030054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030054