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Prostate Stem Cells in the Development of Benign Prostate Hyperplasia and Prostate Cancer: Emerging Role and Concepts
Joint Authors
Gupta, Sarita
Mistry, Bhavesh
Prajapati, Akhilesh
Gupta, Sharad
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Benign Prostate hyperplasia (BPH) and prostate cancer (PCa) are the most common prostatic disorders affecting elderly men.
Multiple factors including hormonal imbalance, disruption of cell proliferation, apoptosis, chronic inflammation, and aging are thought to be responsible for the pathophysiology of these diseases.
Both BPH and PCa are considered to be arisen from aberrant proliferation of prostate stem cells.
Recent studies on BPH and PCa have provided significant evidence for the origin of these diseases from stem cells that share characteristics with normal prostate stem cells.
Aberrant changes in prostate stem cell regulatory factors may contribute to the development of BPH or PCa.
Understanding these regulatory factors may provide insight into the mechanisms that convert quiescent adult prostate cells into proliferating compartments and lead to BPH or carcinoma.
Ultimately, the knowledge of the unique prostate stem or stem-like cells in the pathogenesis and development of hyperplasia will facilitate the development of new therapeutic targets for BPH and PCa.
In this review, we address recent progress towards understanding the putative role and complexities of stem cells in the development of BPH and PCa.
American Psychological Association (APA)
Prajapati, Akhilesh& Gupta, Sharad& Mistry, Bhavesh& Gupta, Sarita. 2013. Prostate Stem Cells in the Development of Benign Prostate Hyperplasia and Prostate Cancer: Emerging Role and Concepts. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030079
Modern Language Association (MLA)
Prajapati, Akhilesh…[et al.]. Prostate Stem Cells in the Development of Benign Prostate Hyperplasia and Prostate Cancer: Emerging Role and Concepts. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030079
American Medical Association (AMA)
Prajapati, Akhilesh& Gupta, Sharad& Mistry, Bhavesh& Gupta, Sarita. Prostate Stem Cells in the Development of Benign Prostate Hyperplasia and Prostate Cancer: Emerging Role and Concepts. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030079