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Immunomodulatory Effect of Continuous Venovenous Hemofiltration during Sepsis: Preliminary Data
Joint Authors
Riccio, Eleonora
Procino, Alfredo
Servillo, Giuseppe
Vargas, Maria
Pastore, Antonio
Memoli, Bruno
Iannuzzi, Michele
Capuano, Alfredo
Memoli, Andrea
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Severe sepsis and septic shock are the primary causes of multiple organ dysfunction syndrome (MODS), which is the most frequent cause of death in intensive care unit patients.
Many pro- and anti-inflammatory mediators, such as interleukin-6 (IL-6), play a strategic role in septic syndrome.
Continuous renal replacement therapy (CRRT) removes in a nonselective way pro- and anti-inflammatory mediators.
Objective.
To investigate the effects of continuous venovenous hemofiltration (CVVH) as an immunomodulatory treatment of sepsis in a prospective clinical study.
Methods.
High flux hemofiltration (Qf = 60 ml/Kg/hr) was performed for 72 hr in thirteen critically ill patients suffering from severe sepsis or septic shock with acute renal failure (ARF).
IL-6 gene expression was measured by real-time PCR analysis on RNA extracted from peripheral blood mononuclear cell before beginning of treatment (T0) and after 12, 24, 48, and 72 hours (T1–4).
Results.
Real-time PCR analysis demonstrated in twelve patients IL-6 mRNA reduction after 12 hours of treatment and a progressive increase after 24, 48, and 72 hours.
Conclusions.
We suggest that an immunomodulatory effect might exist during CVVH performed in critically ill patients with severe sepsis and septic shock.
Our data show that the transcriptional activity of IL-6 increases during CVVH.
American Psychological Association (APA)
Servillo, Giuseppe& Vargas, Maria& Pastore, Antonio& Procino, Alfredo& Iannuzzi, Michele& Capuano, Alfredo…[et al.]. 2013. Immunomodulatory Effect of Continuous Venovenous Hemofiltration during Sepsis: Preliminary Data. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030080
Modern Language Association (MLA)
Servillo, Giuseppe…[et al.]. Immunomodulatory Effect of Continuous Venovenous Hemofiltration during Sepsis: Preliminary Data. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030080
American Medical Association (AMA)
Servillo, Giuseppe& Vargas, Maria& Pastore, Antonio& Procino, Alfredo& Iannuzzi, Michele& Capuano, Alfredo…[et al.]. Immunomodulatory Effect of Continuous Venovenous Hemofiltration during Sepsis: Preliminary Data. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030080