Prevalence of Bronchiectasis in Asthma according to Oral Steroid Requirement: Influence of Immunoglobulin Levels
Joint Authors
Luján, Manel
Gallardo, Xavier
Bosque, Montserrat
Mirapeix, Rosa M.
Domingo, Christian
Amengual, María J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To establish the prevalence of bronchiectasis in asthma in relation to patients’ oral corticosteroid requirements and to explore whether the increased risk is due to blood immunoglobulin (Ig) concentration.
Methods.
Case-control cross-sectional study, including 100 sex- and age-matched patients, 50 with non-steroid-dependent asthma (NSDA) and 50 with steroid-dependent asthma (SDA).
Study protocol: (a) measurement of Ig and gG subclass concentration; (b) forced spirometry; and (c) high-resolution thoracic computed tomography.
When bronchiectasis was detected, a specific etiological protocol was applied to establish its etiology.
Results.
The overall prevalence of bronchiectasis was 12/50 in the SDA group and 6/50 in the NSDA group (p=ns).
The etiology was documented in six patients (four NSDA and two SDA).
After excluding these patients, the prevalence of bronchiectasis was 20% (10/50) in the SDA group and 2/50 (4%) in the NSDA group (P<0.05).
Patients with asthma-associated bronchiectasis presented lower FEV1 values than patients without bronchiectasis, but the levels of Ig and subclasses of IgG did not present differences.
Conclusions.
Steroid-dependent asthma seems to be associated with a greater risk of developing bronchiectasis than non-steroid-dependent asthma.
This is probably due to the disease itself rather than to other influencing factors such as immunoglobulin levels.
American Psychological Association (APA)
Luján, Manel& Gallardo, Xavier& Amengual, María J.& Bosque, Montserrat& Mirapeix, Rosa M.& Domingo, Christian. 2013. Prevalence of Bronchiectasis in Asthma according to Oral Steroid Requirement: Influence of Immunoglobulin Levels. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030081
Modern Language Association (MLA)
Luján, Manel…[et al.]. Prevalence of Bronchiectasis in Asthma according to Oral Steroid Requirement: Influence of Immunoglobulin Levels. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030081
American Medical Association (AMA)
Luján, Manel& Gallardo, Xavier& Amengual, María J.& Bosque, Montserrat& Mirapeix, Rosa M.& Domingo, Christian. Prevalence of Bronchiectasis in Asthma according to Oral Steroid Requirement: Influence of Immunoglobulin Levels. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030081