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SDOCT Thickness Measurements of Various Retinal Layers in Patients with Autosomal Dominant Optic Atrophy due to OPA1 Mutations
Joint Authors
Kirchhof, Bernd
Schild, Andrea M.
Fricke, Julia
Neugebauer, Antje
Ristau, Tina
Liakopoulos, Sandra
Sadda, Srinivas R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
To specify thickness values of various retinal layers on macular spectral domain Optical Coherence Tomography (SDOCT) scans in patients with autosomal dominant optic atrophy (ADOA) compared to healthy controls.
Methods.
SDOCT volume scans of 7 patients with ADOA (OPA-1 mutation) and 14 healthy controls were quantitatively analyzed using manual grading software.
Mean thickness values for the ETDRS grid subfields 5–8 were calculated for the spaces neurosensory retina, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), a combined space of inner plexiform layer/outer plexiform layer/inner nuclear layer (IPL+INL+OPL), and a combined space of outer nuclear layer/photoreceptor layers (ONL+PL).
Results.
ADOA patients showed statistically significant lower retinal thickness values than controls (P<0.01).
RNFL (P<0.001) and GCL thicknesses (P<0.001) were significantly lower in ADOA patients.
There was no difference in IPL+INL+OPL and in ONL+PL thickness.
Conclusion.
Manual subanalysis of macular SDOCT volume scans allowed detailed subanalysis of various retinal layers.
Not only RNFL but also GCL thicknesses are reduced in the macular area of ADOA patients whereas subjacent layers are not involved.
Together with clinical findings, macular SDOCT helps to identify patients with suspicion for hereditary optic neuropathy before genetic analysis confirms the diagnosis.
American Psychological Association (APA)
Schild, Andrea M.& Ristau, Tina& Fricke, Julia& Neugebauer, Antje& Kirchhof, Bernd& Sadda, Srinivas R.…[et al.]. 2013. SDOCT Thickness Measurements of Various Retinal Layers in Patients with Autosomal Dominant Optic Atrophy due to OPA1 Mutations. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030086
Modern Language Association (MLA)
Schild, Andrea M.…[et al.]. SDOCT Thickness Measurements of Various Retinal Layers in Patients with Autosomal Dominant Optic Atrophy due to OPA1 Mutations. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030086
American Medical Association (AMA)
Schild, Andrea M.& Ristau, Tina& Fricke, Julia& Neugebauer, Antje& Kirchhof, Bernd& Sadda, Srinivas R.…[et al.]. SDOCT Thickness Measurements of Various Retinal Layers in Patients with Autosomal Dominant Optic Atrophy due to OPA1 Mutations. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030086