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Participation of GABAA Chloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture
Joint Authors
Contreras, C. M.
Rodríguez-Landa, Juan Francisco
García-Ríos, Rosa Isela
Cueto-Escobedo, Jonathan
Bernal-Morales, Blandina
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Human amniotic fluid and a mixture of eight fatty acids (FAT-M) identified in this maternal fluid (C12:0, lauric acid, 0.9 μg%; C14:0, myristic acid, 6.9 μg%; C16:0, palmitic acid, 35.3 μg%; C16:1, palmitoleic acid, 16.4 μg%; C18:0, stearic acid, 8.5 μg%; C18:1cis, oleic acid, 18.4 μg%; C18:1trans, elaidic acid, 3.5 μg%; C18:2, linoleic acid, 10.1 μg%) produce anxiolytic-like effects that are comparable to diazepam in Wistar rats, suggesting the involvement of γ-aminobutyric acid-A (GABAA) receptors, a possibility not yet explored.
Wistar rats were subjected to the defensive burying test, elevated plus maze, and open field test.
In different groups, three GABAA receptor antagonists were administered 30 min before FAT-M administration, including the competitive GABA binding antagonist bicuculline (1 mg/kg), GABAA benzodiazepine antagonist flumazenil (5 mg/kg), and noncompetitive GABAA chloride channel antagonist picrotoxin (1 mg/kg).
The FAT-M exerted anxiolytic-like effects in the defensive burying test and elevated plus maze, without affecting locomotor activity in the open field test.
The GABAA antagonists alone did not produce significant changes in the behavioral tests.
Picrotoxin but not bicuculline or flumazenil blocked the anxiolytic-like effect of the FAT-M.
Based on the specific blocking action of picrotoxin on the effects of the FAT-M, we conclude that the FAT-M exerted its anxiolytic-like effects through GABAA receptor chloride channels.
American Psychological Association (APA)
Rodríguez-Landa, Juan Francisco& García-Ríos, Rosa Isela& Cueto-Escobedo, Jonathan& Bernal-Morales, Blandina& Contreras, C. M.. 2013. Participation of GABAA Chloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030087
Modern Language Association (MLA)
Rodríguez-Landa, Juan Francisco…[et al.]. Participation of GABAA Chloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030087
American Medical Association (AMA)
Rodríguez-Landa, Juan Francisco& García-Ríos, Rosa Isela& Cueto-Escobedo, Jonathan& Bernal-Morales, Blandina& Contreras, C. M.. Participation of GABAA Chloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030087