MicroRNAs in Kidney Fibrosis and Diabetic Nephropathy: Roles on EMT and EndMT
Joint Authors
Srivastava, Swayam Prakash
Kanasaki, Keizo
Koya, Daisuke
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are a family of small, noncoding RNAs that regulate gene expression in diverse biological and pathological processes, including cell proliferation, differentiation, apoptosis, and carcinogenesis.
As a result, miRNAs emerged as major area of biomedical research with relevance to kidney fibrosis.
Fibrosis is characterized by the excess deposition of extracellular matrix (ECM) components, which is the end result of an imbalance of metabolism of the ECM molecule.
Recent evidence suggests that miRNAs participate in the fibrotic process in a number of organs including the heart, kidney, liver, and lung.
Epithelial mesenchymal transition (EMT) and endothelial mesenchymal transition (EndMT) programs play vital roles in the development of fibrosis in the kidney.
A growing number of the extracellular and intracellular molecules that control EMT and EndMT have been identified and could be exploited in developing therapeutics for fibrosis.
This review highlights recent advances on the role of miRNAs in the kidney diseases; diabetic nephropathy especially focused on EMT and EndMT program responsible for the development of kidney fibrosis.
These miRNAs can be utilized as a potential novel drug target for the studying of underlying mechanism and treatment of kidney fibrosis.
American Psychological Association (APA)
Srivastava, Swayam Prakash& Koya, Daisuke& Kanasaki, Keizo. 2013. MicroRNAs in Kidney Fibrosis and Diabetic Nephropathy: Roles on EMT and EndMT. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030090
Modern Language Association (MLA)
Srivastava, Swayam Prakash…[et al.]. MicroRNAs in Kidney Fibrosis and Diabetic Nephropathy: Roles on EMT and EndMT. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030090
American Medical Association (AMA)
Srivastava, Swayam Prakash& Koya, Daisuke& Kanasaki, Keizo. MicroRNAs in Kidney Fibrosis and Diabetic Nephropathy: Roles on EMT and EndMT. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030090