Emerging Therapeutic Biomarkers in Endometrial Cancer
Joint Authors
Dong, Peixin
Kaneuchi, Masanori
Konno, Yosuke
Watari, Hidemichi
Sudo, Satoko
Sakuragi, Noriaki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Although clinical trials of molecular therapies targeting critical biomarkers (mTOR, epidermal growth factor receptor/epidermal growth factor receptor 2, and vascular endothelial growth factor) in endometrial cancer show modest effects, there are still challenges that might remain regarding primary/acquired drug resistance and unexpected side effects on normal tissues.
New studies that aim to target both genetic and epigenetic alterations (noncoding microRNA) underlying malignant properties of tumor cells and to specifically attack tumor cells using cell surface markers overexpressed in tumor tissue are emerging.
More importantly, strategies that disrupt the cancer stem cell/epithelial-mesenchymal transition-dependent signals and reactivate antitumor immune responses would bring new hope for complete elimination of all cell compartments in endometrial cancer.
We briefly review the current status of molecular therapies tested in clinical trials and mainly discuss the potential therapeutic candidates that are possibly used to develop more effective and specific therapies against endometrial cancer progression and metastasis.
American Psychological Association (APA)
Dong, Peixin& Kaneuchi, Masanori& Konno, Yosuke& Watari, Hidemichi& Sudo, Satoko& Sakuragi, Noriaki. 2013. Emerging Therapeutic Biomarkers in Endometrial Cancer. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030093
Modern Language Association (MLA)
Dong, Peixin…[et al.]. Emerging Therapeutic Biomarkers in Endometrial Cancer. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030093
American Medical Association (AMA)
Dong, Peixin& Kaneuchi, Masanori& Konno, Yosuke& Watari, Hidemichi& Sudo, Satoko& Sakuragi, Noriaki. Emerging Therapeutic Biomarkers in Endometrial Cancer. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030093