In Vitro Release Kinetics of Antituberculosis Drugs from Nanoparticles Assessed Using a Modified Dissolution Apparatus
Joint Authors
Bou-Chacra, Nádia
Gao, Yuan
Zuo, Jieyu
Pinto, Terezinha de Jesus Andreoli
Clas, Sophie-Dorothee
Walker, Roderick B.
Löbenberg, Raimar
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was to assess the in vitro release kinetics of antituberculosis drug-loaded nanoparticles (NPs) using a “modified” cylindrical apparatus fitted with a regenerated cellulose membrane attached to a standard dissolution apparatus (modifiedcylinder method).
The model drugs that were used were rifampicin (RIF) and moxifloxacin hydrochloride (MX).
Gelatin and polybutyl cyanoacrylate (PBCA) NPs were evaluated as the nanocarriers, respectively.
The dissolution and release kinetics of the drugs from loaded NPs were studied in different media using the modified cylinder method and dialysis bag technique was used as the control technique.
The results showed that use of the modified cylinder method resulted in different release profiles associated with unique release mechanisms for the nanocarrier systems investigated.
The modified cylinder method also permitted discrimination between forced and normal in vitro release of the model drugs from gelatin NPs in the presence or absence of enzymatic degradation.
The use of dialysis bag technique resulted in an inability to differentiate between the mechanisms of drug release from the NPs in these cases.
This approach offers an effective tool to investigate in vitro release of RIF and MX from NPs, which further indicate that this technique can be used for performance testing of nanosized carrier systems.
American Psychological Association (APA)
Gao, Yuan& Zuo, Jieyu& Bou-Chacra, Nádia& Pinto, Terezinha de Jesus Andreoli& Clas, Sophie-Dorothee& Walker, Roderick B.…[et al.]. 2013. In Vitro Release Kinetics of Antituberculosis Drugs from Nanoparticles Assessed Using a Modified Dissolution Apparatus. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030098
Modern Language Association (MLA)
Gao, Yuan…[et al.]. In Vitro Release Kinetics of Antituberculosis Drugs from Nanoparticles Assessed Using a Modified Dissolution Apparatus. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030098
American Medical Association (AMA)
Gao, Yuan& Zuo, Jieyu& Bou-Chacra, Nádia& Pinto, Terezinha de Jesus Andreoli& Clas, Sophie-Dorothee& Walker, Roderick B.…[et al.]. In Vitro Release Kinetics of Antituberculosis Drugs from Nanoparticles Assessed Using a Modified Dissolution Apparatus. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030098
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030098