Ursodeoxycholic Acid Improves Bilirubin but Not Albumin in PrimaryBiliary Cirrhosis: Further Evidence for Nonefficacy
Joint Authors
Feudjo, Maurille
Vlachogiannakos, Jiannis
Rigamonti, Cristina
Carpenter, James
Burroughs, Andrew K.
Tsochatzis, Emmanuel A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background/Aim.
In randomised controlled trials (RCTs) of ursodeoxycholic acid (UDCA), although serum bilirubin is frequently reduced, its effect on disease progression and mortality is unclear.
As serum albumin is an established independent prognostic marker, one might expect less deterioration of serum albumin values in a UDCA-treated group.
We therefore modelled the typical evolution of serum bilirubin and albumin levels over time in UDCA-untreated patients and compared it with the observed levels in UDCA RCTs.
Methods.
Multilevel modelling was used to relate the evolution of serum albumin to serum bilirubin and time since patient referral.
For each considered RCT, the derived model was used to predict the relationship between final mean serum albumin and bilirubin concentration, adjusted for mean serum albumin at referral and followup duration.
Results.
Five RCTs were eligible in terms of available data, of which two had long followup.
In all trials, serum albumin did not significantly differ between UDCA- and placebo-treated patients, despite the UDCA effect on serum bilirubin.
Therefore, there is no evidence over time for changes or maintenance of albumin levels for UDCA-treated patients above the levels predicted for placebo-treated patients.
Conclusions.
Our findings suggest that UDCA does not alter serum albumin in a way that is consistent with its effect on serum bilirubin.
Therefore, reductions in serum bilirubin of UDCA-treated PBC do not parallel another validated and independent prognostic marker, further questioning the validity of serum bilirubin reduction with UDCA as a surrogate therapeutic marker.
American Psychological Association (APA)
Tsochatzis, Emmanuel A.& Feudjo, Maurille& Rigamonti, Cristina& Vlachogiannakos, Jiannis& Carpenter, James& Burroughs, Andrew K.. 2013. Ursodeoxycholic Acid Improves Bilirubin but Not Albumin in PrimaryBiliary Cirrhosis: Further Evidence for Nonefficacy. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030104
Modern Language Association (MLA)
Tsochatzis, Emmanuel A.…[et al.]. Ursodeoxycholic Acid Improves Bilirubin but Not Albumin in PrimaryBiliary Cirrhosis: Further Evidence for Nonefficacy. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030104
American Medical Association (AMA)
Tsochatzis, Emmanuel A.& Feudjo, Maurille& Rigamonti, Cristina& Vlachogiannakos, Jiannis& Carpenter, James& Burroughs, Andrew K.. Ursodeoxycholic Acid Improves Bilirubin but Not Albumin in PrimaryBiliary Cirrhosis: Further Evidence for Nonefficacy. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030104