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Pre- and Postsynaptic Dopamine SPECT in Idiopathic Parkinsonian Diseases: A Follow-Up Study
Joint Authors
Jakobson Mo, Susanna
Forsgren, Lars
Holmberg, Henrik
Larsson, Anne
Riklund, Katrine
Linder, Jan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
We prospectively evaluated the diagnostic contribution of 123I-FP-Cit (DAT) and 123I-IBZM (IBZM) SPECT in 29 patients with Parkinson's disease (PD) (74.4±4.2 years) and 28 patients with atypical parkinsonian diseases (APD) (74.3±9.2 years).
Twelve had multiple system atrophy (MSA) and 16 progressive supranuclear palsy (PSP).
Sixteen age-matched healthy controls (HC) were included.
DAT and IBZM SPECTs were made at baseline and after 1 year in all PD patients and in 20 (DAT) and 18 (IBZM) of the APD patients, and after 3 years in 22 (DAT) and 17 (IBZM) of the PD patients and in 10 (DAT) and 10 (IBZM) of the APD patients.
The relative DAT uptake decrease was faster in PD and PSP than in HC and MSA.
In PSP the DAT uptake was lower than in MSA after 1 year but not after 3 years.
Baseline IBZM uptake was not significantly different between patients and HC or between PD and APD.
One year after initiated dopaminergic treatment the mean IBZM uptake in the MSA patients remained high compared to PSP and after 3 years compared to PD, PSP, and HC.
Thus, the pattern of uptake of these ligands over time may be of value in discriminating between these diagnoses.
American Psychological Association (APA)
Jakobson Mo, Susanna& Linder, Jan& Forsgren, Lars& Holmberg, Henrik& Larsson, Anne& Riklund, Katrine. 2013. Pre- and Postsynaptic Dopamine SPECT in Idiopathic Parkinsonian Diseases: A Follow-Up Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030111
Modern Language Association (MLA)
Jakobson Mo, Susanna…[et al.]. Pre- and Postsynaptic Dopamine SPECT in Idiopathic Parkinsonian Diseases: A Follow-Up Study. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1030111
American Medical Association (AMA)
Jakobson Mo, Susanna& Linder, Jan& Forsgren, Lars& Holmberg, Henrik& Larsson, Anne& Riklund, Katrine. Pre- and Postsynaptic Dopamine SPECT in Idiopathic Parkinsonian Diseases: A Follow-Up Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030111