The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population
Joint Authors
Watanabe, Maria Angélica Ehara
Consolaro, Marcia Edilaine Lopes
Marangon, Amanda Vansan
Guelsin, Gláucia Andreia Soares
Visentainer, Jeane Eliete Laguila
Borelli, Sueli Donizete
Sell, Ana Maria
Caleffi-Ferracioli, Katiany Rizzieri
Rudnick, Cristiane Conceição Chagas
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The genetic variability of the host contributes to the risk of human papillomavirus (HPV)-related cervical disease.
Immune response genes to HPV must be investigated to define patients with the highest risk of developing malignant disease.
The aim of this study was to investigate the association of polymorphic immune response genes, namely KIR, HLA class I and II, and single-nucleotide polymorphisms (SNPs) of cytokines with HPV-related cervical disease.
We selected 79 non-related, admixed Brazilian women from the state of Paraná, southern region of Brazil, who were infected with high carcinogenic risk HPV and present cervical intraepithelial neoplasia grade 3 (CIN3), and 150 HPV-negative women from the same region matched for ethnicity.
KIR genes were genotyped using an in-house PCR-SSP.
HLA alleles were typed using a reverse sequence-specific oligonucleotide technique.
SNPs of TNF −308G>A, IL6 −174G>C, IFNG +874T>A, TGFB1 +869T>C +915G>C, and IL10 −592C>A −819C>T −1082G>A were evaluated using PCR-SSP.
The KIR genes were not associated with HPV, although some pairs of i(inhibitory)KIR-ligands occurred more frequently in patients, supporting a role for NK in detrimental chronic inflammatory and carcinogenesis.
Some HLA haplotypes were associated with HPV.
The associations of INFG and IL10 SNPs potentially reflect impaired or invalid responses in advanced lesions.
American Psychological Association (APA)
Marangon, Amanda Vansan& Guelsin, Gláucia Andreia Soares& Visentainer, Jeane Eliete Laguila& Borelli, Sueli Donizete& Watanabe, Maria Angélica Ehara& Consolaro, Marcia Edilaine Lopes…[et al.]. 2013. The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030114
Modern Language Association (MLA)
Marangon, Amanda Vansan…[et al.]. The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030114
American Medical Association (AMA)
Marangon, Amanda Vansan& Guelsin, Gláucia Andreia Soares& Visentainer, Jeane Eliete Laguila& Borelli, Sueli Donizete& Watanabe, Maria Angélica Ehara& Consolaro, Marcia Edilaine Lopes…[et al.]. The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030114