Skeletal Muscle Regeneration on Protein-Grafted and Microchannel-Patterned Scaffold for Hypopharyngeal Tissue Engineering
Joint Authors
Shen, Zhisen
Zhu, Yabin
Guo, Shanshan
Ye, Dong
Chen, Jingjing
Kang, Cheng
Qiu, Shejie
Lu, Dakai
Li, Qun
Xu, Kunjie
Lv, Jingjing
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the field of tissue engineering, polymeric materials with high biocompatibility like polylactic acid and polyglycolic acid have been widely used for fabricating living constructs.
For hypopharynx tissue engineering, skeletal muscle is one important functional part of the whole organ, which assembles the unidirectionally aligned myotubes.
In this study, a polyurethane (PU) scaffold with microchannel patterns was used to provide aligning guidance for the seeded human myoblasts.
Due to the low hydrophilicity of PU, the scaffold was grafted with silk fibroin (PU-SF) or gelatin (PU-Gel) to improve its cell adhesion properties.
Scaffolds were observed to degrade slowly over time, and their mechanical properties and hydrophilicities were improved through the surface grafting.
Also, the myoblasts seeded on PU-SF had the higher proliferative rate and better differentiation compared with those on the control or PU-Gel.
Our results demonstrate that polyurethane scaffolds seeded with myoblasts hold promise to guide hypopharynx muscle regeneration.
American Psychological Association (APA)
Shen, Zhisen& Guo, Shanshan& Ye, Dong& Chen, Jingjing& Kang, Cheng& Qiu, Shejie…[et al.]. 2013. Skeletal Muscle Regeneration on Protein-Grafted and Microchannel-Patterned Scaffold for Hypopharyngeal Tissue Engineering. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030115
Modern Language Association (MLA)
Shen, Zhisen…[et al.]. Skeletal Muscle Regeneration on Protein-Grafted and Microchannel-Patterned Scaffold for Hypopharyngeal Tissue Engineering. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030115
American Medical Association (AMA)
Shen, Zhisen& Guo, Shanshan& Ye, Dong& Chen, Jingjing& Kang, Cheng& Qiu, Shejie…[et al.]. Skeletal Muscle Regeneration on Protein-Grafted and Microchannel-Patterned Scaffold for Hypopharyngeal Tissue Engineering. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030115