S100A12 and hBD2 Correlate with the Composition of the Fecal Microflora in ELBW Infants and Expansion of E. coli Is Associated with NEC

Joint Authors

Wirth, S.
Hensel, Kai O.
Postberg, J.
Mariel, B.
Foell, D.
Däbritz, J.
Jenke, Andreas

Source

BioMed Research International

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-11-06

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Objective.

To describe the development of the gut microbiota in extremely low birth weight (ELBW) infants with and without necrotizing enterocolitis (NEC) between April 2008 and December 2009, fecal microflora was prospectively analyzed in fecal samples of all ELBW infants using real-time PCR assays.

In addition, fecal inflammatory were measured.

Results.

Fecal microflora established early in ELBW infants and microbiota composition remained stable over the first 28 days of life except for the prevalence of C.

difficile which decreased with decreasing antibiotic use.

Infants who subsequently developed NEC had an increase of total bacterial count (9.8-fold) 24 h prior to clinical symptoms mainly due to the expansion of E.

coli species (21.6-fold), whereas microbiota composition did not differ from healthy ELBW infants five days before onset of NEC.

Importantly, S100A12 and hBD2 positively correlated with the total and E.

coli bacterial CFU/g feces (r2 0.4 and 0.64, resp.).

Conclusions.

In summary, we found evidence for a disturbed homeostasis between the intestinal microbiome and host immunity in ELBW infants with NEC.

Moreover, S100A12 and hBD2 correlate with the fecal microbiota thus linking the intestinal innate immune response to the bacterial colonization thus possibly providing a diagnostic tool in the future.

American Psychological Association (APA)

Jenke, Andreas& Postberg, J.& Mariel, B.& Hensel, Kai O.& Foell, D.& Däbritz, J.…[et al.]. 2013. S100A12 and hBD2 Correlate with the Composition of the Fecal Microflora in ELBW Infants and Expansion of E. coli Is Associated with NEC. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030122

Modern Language Association (MLA)

Jenke, Andreas…[et al.]. S100A12 and hBD2 Correlate with the Composition of the Fecal Microflora in ELBW Infants and Expansion of E. coli Is Associated with NEC. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030122

American Medical Association (AMA)

Jenke, Andreas& Postberg, J.& Mariel, B.& Hensel, Kai O.& Foell, D.& Däbritz, J.…[et al.]. S100A12 and hBD2 Correlate with the Composition of the Fecal Microflora in ELBW Infants and Expansion of E. coli Is Associated with NEC. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030122

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1030122