Perinatal Exposure to Insecticide Methamidophos Suppressed Production of Proinflammatory Cytokines Responding to Virus Infection in Lung Tissues in Mice
Joint Authors
Watanabe, Wataru
Takeshita, Tomomi
Yoshida, Hiroki
Hirose, Akihiko
Akashi, Toshi
Kuroki, Nao
Shibata, Asami
Hongo, Satoko
Hashiguchi, Seiko
Konno, Katsuhiko
Kurokawa, Masahiko
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Methamidophos, a representative organophosphate insecticide, is regulated because of its severe neurotoxicity, but it is suspected of contaminating agricultural foods in many countries due to illicit use.
To reveal unknown effects of methamidophos on human health, we evaluated the developmental immunotoxicity of methamidophos using a respiratory syncytial virus (RSV) infection mouse model.
Pregnant mice were exposed to methamidophos (10 or 20 ppm) in their drinking water from gestation day 10 to weaning on postnatal day 21.
Offsprings born to these dams were intranasally infected with RSV.
The levels of interleukin-6 (IL-6) and interferon-gamma in the bronchoalveolar lavage fluids after infection were significantly decreased in offspring mice exposed to methamidophos.
Treatment with methamidophos did not affect the pulmonary viral titers but suppressed moderately the inflammation of lung tissues of RSV-infected offspring, histopathologically.
DNA microarray analysis revealed that gene expression of the cytokines in the lungs of offspring mice exposed to 20 ppm of methamidophos was apparently suppressed compared with the control.
Methamidophos did not suppress IL-6 production in RSV-infected J774.1 cell cultures.
Thus, exposure of the mother to methamidophos during pregnancy and nursing was suggested to cause an irregular immune response in the lung tissues in the offspring mice.
American Psychological Association (APA)
Watanabe, Wataru& Yoshida, Hiroki& Hirose, Akihiko& Akashi, Toshi& Takeshita, Tomomi& Kuroki, Nao…[et al.]. 2013. Perinatal Exposure to Insecticide Methamidophos Suppressed Production of Proinflammatory Cytokines Responding to Virus Infection in Lung Tissues in Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030126
Modern Language Association (MLA)
Watanabe, Wataru…[et al.]. Perinatal Exposure to Insecticide Methamidophos Suppressed Production of Proinflammatory Cytokines Responding to Virus Infection in Lung Tissues in Mice. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030126
American Medical Association (AMA)
Watanabe, Wataru& Yoshida, Hiroki& Hirose, Akihiko& Akashi, Toshi& Takeshita, Tomomi& Kuroki, Nao…[et al.]. Perinatal Exposure to Insecticide Methamidophos Suppressed Production of Proinflammatory Cytokines Responding to Virus Infection in Lung Tissues in Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030126