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Safety Evaluation of Turmeric Polysaccharide Extract: Assessment of Mutagenicity and Acute Oral Toxicity
Joint Authors
Velusami, Chandrasekaran Chinampudur
Agarwal, Amit
Boddapati, Srinivasa Rao
Hongasandra Srinivasa, Srikanth
Richard, Edwin Jothie
Balasubramanian, Murali
Allan, Joseph Joshua
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Curcuma longa Linn.
(Zingiberaceae) commonly known as turmeric has long been used for centuries as a spice and household remedy.
The present study was carried out to assess the possible mutagenic potential and acute oral toxicity of polysaccharide extract of turmeric rhizome (NR-INF-02) using standard tests.
The standard battery of in vitro genotoxicity tests, bacterial reverse mutation test (BRMT), chromosome aberration (CA), and micronucleus (MN) tests were employed to assess the possible mutagenic activity of NR-INF-02 (Turmacin).
The results showed no mutagenic effect with NR-INF-02 up to a dose of 5000 µg/mL in BRMT.
The results on CA and MN tests revealed the non clastogenic activity of NR-INF-02 in a dose range of 250.36 to 2500 µg/mL with and without metabolic activation (S9).
In acute oral toxicity study, NR-INF-02 was found to be safe up to 5 g/kg body weight in Wistar rats.
Overall, results indicated that polysaccharide extract of C.
longa was found to be genotoxically safe and also exhibited maximum tolerable dose of more than 5 g/kg rat body weight.
American Psychological Association (APA)
Velusami, Chandrasekaran Chinampudur& Boddapati, Srinivasa Rao& Hongasandra Srinivasa, Srikanth& Richard, Edwin Jothie& Allan, Joseph Joshua& Balasubramanian, Murali…[et al.]. 2013. Safety Evaluation of Turmeric Polysaccharide Extract: Assessment of Mutagenicity and Acute Oral Toxicity. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030142
Modern Language Association (MLA)
Velusami, Chandrasekaran Chinampudur…[et al.]. Safety Evaluation of Turmeric Polysaccharide Extract: Assessment of Mutagenicity and Acute Oral Toxicity. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030142
American Medical Association (AMA)
Velusami, Chandrasekaran Chinampudur& Boddapati, Srinivasa Rao& Hongasandra Srinivasa, Srikanth& Richard, Edwin Jothie& Allan, Joseph Joshua& Balasubramanian, Murali…[et al.]. Safety Evaluation of Turmeric Polysaccharide Extract: Assessment of Mutagenicity and Acute Oral Toxicity. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030142