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Gemifloxacin, a Fluoroquinolone Antimicrobial Drug, Inhibits Migration and Invasion of Human Colon Cancer Cells
Joint Authors
Chen, T.-C.
Kan, Jung-Yu
Chen, Yen-Hsu
Kuo, Po-Lin
Wang, Jaw-Yuan
Hsu, Ya-Ling
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Gemifloxacin (GMF) is an orally administered broad-spectrum fluoroquinolone antimicrobial agent used to treat acute bacterial exacerbation of pneumonia and bronchitis.
Although fluoroquinolone antibiotics have also been found to have anti-inflammatory and anticancer effects, studies on the effect of GMF on treating colon cancer have been relatively rare.
To the best of our knowledge, this is the first report to describe the antimetastasis activities of GMF in colon cancer and the possible mechanisms involved.
Results have shown that GMF inhibits the migration and invasion of colon cancer SW620 and LoVo cells and causes epithelial mesenchymal transition (EMT).
In addition, GMF suppresses the activation of NF-κB and cell migration and invasion induced by TNF-α and inhibits the TAK1/TAB2 interaction, resulting in decreased IκB phosphorylation and NF-κB nuclear translocation in SW620 cells.
Furthermore, Snail, a critical transcriptional factor of EMT, was downregulated after GMF treatment.
Overexpression of Snail by cDNA transfection significantly decreases the inhibitory effect of GMF on EMT and cell migration and invasion.
In conclusion, GMF may be a novel anticancer agent for the treatment of metastasis in colon cancer.
American Psychological Association (APA)
Kan, Jung-Yu& Hsu, Ya-Ling& Chen, Yen-Hsu& Chen, T.-C.& Wang, Jaw-Yuan& Kuo, Po-Lin. 2013. Gemifloxacin, a Fluoroquinolone Antimicrobial Drug, Inhibits Migration and Invasion of Human Colon Cancer Cells. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030143
Modern Language Association (MLA)
Kan, Jung-Yu…[et al.]. Gemifloxacin, a Fluoroquinolone Antimicrobial Drug, Inhibits Migration and Invasion of Human Colon Cancer Cells. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030143
American Medical Association (AMA)
Kan, Jung-Yu& Hsu, Ya-Ling& Chen, Yen-Hsu& Chen, T.-C.& Wang, Jaw-Yuan& Kuo, Po-Lin. Gemifloxacin, a Fluoroquinolone Antimicrobial Drug, Inhibits Migration and Invasion of Human Colon Cancer Cells. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030143