Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis
Joint Authors
Fan, Chao
Zhou, Yanxia
Zhao, Yong
Ma, Shujin
Li, Wenjing
Li, Guiling
Li, Xinru
Liu, Yan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The purpose of this work was to explore the feasibility of ethosomes for improving the antiarthritic efficacy of tetrandrine by topical application.
It was found that tetrandrine was a weak base (pKa=7.06) with pH-dependent partition coefficient.
The spherical-shaped ethosomes were prepared by pH gradient loading method.
Ex vivo permeation and deposition behavior demonstrated that the drug flux across rat skin and deposition of the drug in rat skin for ethosomes was 2.1- and 1.7-fold higher than that of liposomes, respectively.
Confocal laser scanning microscopy confirmed that ethosomes could enhance the topical delivery of the drug in terms of depth and quantity compared with liposomes.
The ethosomes were shown to generate substantial enhancement of therapeutic efficacy of tetrandrine on Freund’s complete adjuvant-induced arthritis with regard to liposomes.
These results indicated that ethosomes would be a promising carrier for topical delivery of tetrandrine into and across the skin.
American Psychological Association (APA)
Fan, Chao& Li, Xinru& Zhou, Yanxia& Zhao, Yong& Ma, Shujin& Li, Wenjing…[et al.]. 2013. Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030146
Modern Language Association (MLA)
Fan, Chao…[et al.]. Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1030146
American Medical Association (AMA)
Fan, Chao& Li, Xinru& Zhou, Yanxia& Zhao, Yong& Ma, Shujin& Li, Wenjing…[et al.]. Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030146