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FISH Detection of PML-RARA Fusion in ins(15;17) Acute Promyelocytic Leukaemia Depends on Probe Size
Joint Authors
Campbell, Lynda J.
Oei, Paul
Brookwell, Ross
Shortt, Jake
Eaddy, Nicola
Ng, Ashley
Chew, Edward
Browett, Peter
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The diagnosis of acute promyelocytic leukaemia (APL) is usually confirmed by cytogenetics showing the characteristic t(15;17), but a minority of patients have a masked PML/RARA fusion.
We report ten patients with APL and no evidence of the t(15;17), in whom the insertion of RARA into PML could not be demonstrated by initial FISH studies using a standard dual fusion probe but was readily identified using smaller probes.
Given the need for rapid diagnosis of APL, it is important to be aware of the false negative rate for large PML/RARA FISH probes in the setting of masked rearrangements.
American Psychological Association (APA)
Campbell, Lynda J.& Oei, Paul& Brookwell, Ross& Shortt, Jake& Eaddy, Nicola& Ng, Ashley…[et al.]. 2013. FISH Detection of PML-RARA Fusion in ins(15;17) Acute Promyelocytic Leukaemia Depends on Probe Size. BioMed Research International،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1030147
Modern Language Association (MLA)
Campbell, Lynda J.…[et al.]. FISH Detection of PML-RARA Fusion in ins(15;17) Acute Promyelocytic Leukaemia Depends on Probe Size. BioMed Research International No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1030147
American Medical Association (AMA)
Campbell, Lynda J.& Oei, Paul& Brookwell, Ross& Shortt, Jake& Eaddy, Nicola& Ng, Ashley…[et al.]. FISH Detection of PML-RARA Fusion in ins(15;17) Acute Promyelocytic Leukaemia Depends on Probe Size. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1030147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030147