Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications

Joint Authors

Sheraz, Muhammad Ali
Istanbullu, Hilal
Rehman, Ihtesham ur
Ahmed, Sofia

Source

BioMed Research International

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-09-01

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA).

Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1 : 2 and 1 : 5 in Tetrahydrofuran (THF) or THF-ethanol mixtures.

The prepared films were characterized using X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and release studies.

The results indicate transformation of crystalline TA to its amorphous form.

The degree of crystallinity changes both by increasing the polymer concentration and solvent used for the film preparations.

The release profiles of TA were also found to be affected, showing a decrease from approximately 50% to 25% from 1 : 2 to 1 : 5 ratios, respectively.

American Psychological Association (APA)

Istanbullu, Hilal& Ahmed, Sofia& Sheraz, Muhammad Ali& Rehman, Ihtesham ur. 2013. Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030160

Modern Language Association (MLA)

Istanbullu, Hilal…[et al.]. Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030160

American Medical Association (AMA)

Istanbullu, Hilal& Ahmed, Sofia& Sheraz, Muhammad Ali& Rehman, Ihtesham ur. Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030160

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1030160