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Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications
Joint Authors
Sheraz, Muhammad Ali
Istanbullu, Hilal
Rehman, Ihtesham ur
Ahmed, Sofia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA).
Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1 : 2 and 1 : 5 in Tetrahydrofuran (THF) or THF-ethanol mixtures.
The prepared films were characterized using X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and release studies.
The results indicate transformation of crystalline TA to its amorphous form.
The degree of crystallinity changes both by increasing the polymer concentration and solvent used for the film preparations.
The release profiles of TA were also found to be affected, showing a decrease from approximately 50% to 25% from 1 : 2 to 1 : 5 ratios, respectively.
American Psychological Association (APA)
Istanbullu, Hilal& Ahmed, Sofia& Sheraz, Muhammad Ali& Rehman, Ihtesham ur. 2013. Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030160
Modern Language Association (MLA)
Istanbullu, Hilal…[et al.]. Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030160
American Medical Association (AMA)
Istanbullu, Hilal& Ahmed, Sofia& Sheraz, Muhammad Ali& Rehman, Ihtesham ur. Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030160