Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats
Joint Authors
Chen, Yeng
Ibrahim, Darah
Yuet Ping, Kwan
Sreeramanan, Subramaniam
Sasidharan, Sreenivasan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Despite Euphorbia hirta L.
ethnomedicinal benefits, very few studies have described the potential toxicity.
The aim of the present study was to evaluate the in vivo toxicity of methanolic extracts of E.
hirta.
The acute and subchronic oral toxicity of E.
hirta was evaluated in Sprague Dawley rats.
The extract at a single dose of 5000 mg/kg did not produce treatment related signs of toxicity or mortality in any of the animals tested during the 14-day observation period.
Therefore, the LD 50 of this plant was estimated to be more than 5000 mg/kg.
In the repeated dose 90-day oral toxicity study, the administration of 50 mg/kg, 250 mg/kg, and 1000 mg/kg/day of E.
hirta extract per body weight revealed no significant difference (P>0.05) in food and water consumptions, body weight change, haematological and biochemical parameters, relative organ weights, and gross findings compared to the control group.
Macropathology and histopathology examinations of all organs including the liver did not reveal morphological alteration.
Analyses of these results with the information of signs, behaviour, and health monitoring could lead to the conclusion that the long-term oral administration of E.
hirta extract for 90 days does not cause sub-chronic toxicity.
American Psychological Association (APA)
Yuet Ping, Kwan& Ibrahim, Darah& Chen, Yeng& Sreeramanan, Subramaniam& Sasidharan, Sreenivasan. 2013. Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030164
Modern Language Association (MLA)
Yuet Ping, Kwan…[et al.]. Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1030164
American Medical Association (AMA)
Yuet Ping, Kwan& Ibrahim, Darah& Chen, Yeng& Sreeramanan, Subramaniam& Sasidharan, Sreenivasan. Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030164