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Role of Dopaminergic Receptors in Glaucomatous Disease Modulation
Joint Authors
Pescosolido, Nicola
Russo, Paola
Buomprisco, Giuseppe
Nebbioso, Marcella
Parisi, Francesco
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Both studies on animals and humans suggest the presence of dopamine (DA) receptors in the anterior segment of the eye.
Their role in the dynamics of intraocular pressure (IOP) is not yet clear.
DA2 and DA3 receptors are mainly located on postganglionic sympathetic nerve endings.
Their stimulation reduces the release of norepinephrine and suppresses the production of aqueous humor.
DA1 receptors seem to be more expressed by the ciliary body and the outflow pathway of aqueous humor.
The administration of DA1-selective agonists stimulates the production of aqueous humor, increasing IOP, whereas DA2- and DA3-selective agonists could reduce IOP and, therefore, the risk to develop a glaucoma (GL).
GL is a broad spectrum of eye diseases which have in common the damage to the optic nerve and the progressive loss of the visual field.
Further studies are desirable to clarify the role of the dopaminergic system and the usefulness of DA2 and DA3 agonists in reducing IOP.
American Psychological Association (APA)
Pescosolido, Nicola& Parisi, Francesco& Russo, Paola& Buomprisco, Giuseppe& Nebbioso, Marcella. 2013. Role of Dopaminergic Receptors in Glaucomatous Disease Modulation. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030178
Modern Language Association (MLA)
Pescosolido, Nicola…[et al.]. Role of Dopaminergic Receptors in Glaucomatous Disease Modulation. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030178
American Medical Association (AMA)
Pescosolido, Nicola& Parisi, Francesco& Russo, Paola& Buomprisco, Giuseppe& Nebbioso, Marcella. Role of Dopaminergic Receptors in Glaucomatous Disease Modulation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030178