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Analysis of Structures, Functions, and Epitopes of Cysteine Protease from Spirometra erinaceieuropaei Spargana
Joint Authors
Wang, Zhong Quan
Cui, Jing
Liu, Li Na
Zhang, Xi
Wei, Tong
Jiang, Peng
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Spirometra erinaceieuropaei cysteine protease (SeCP) in sparganum ES proteins recognized by early infection sera was identified by MALDI-TOF/TOF-MS.
The aim of this study was to predict the structures and functions of SeCP protein by using the full length cDNA sequence of SeCP gene with online sites and software programs.
The SeCP gene sequence was of 1 053 bp length with a 1011 bp biggest ORF encoding 336-amino acid protein with a complete cathepsin propeptide inhibitor domain and a peptidase C1A conserved domain.
The predicted molecular weight and isoelectric point of SeCP were 37.87 kDa and 6.47, respectively.
The SeCP has a signal peptide site and no transmembrane domain, located outside the membrane.
The secondary structure of SeCP contained 8 α-helixes, 7 β-strands, and 20 coils.
The SeCP had 15 potential antigenic epitopes and 19 HLA-I restricted epitopes.
Based on the phylogenetic analysis of SeCP, S.
erinaceieuropaei has the closest evolutionary status with S.
mansonoides.
SeCP was a kind of proteolytic enzyme with a variety of biological functions and its antigenic epitopes could provide important insights on the diagnostic antigens and target molecular of antisparganum drugs.
American Psychological Association (APA)
Liu, Li Na& Cui, Jing& Zhang, Xi& Wei, Tong& Jiang, Peng& Wang, Zhong Quan. 2013. Analysis of Structures, Functions, and Epitopes of Cysteine Protease from Spirometra erinaceieuropaei Spargana. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030186
Modern Language Association (MLA)
Liu, Li Na…[et al.]. Analysis of Structures, Functions, and Epitopes of Cysteine Protease from Spirometra erinaceieuropaei Spargana. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030186
American Medical Association (AMA)
Liu, Li Na& Cui, Jing& Zhang, Xi& Wei, Tong& Jiang, Peng& Wang, Zhong Quan. Analysis of Structures, Functions, and Epitopes of Cysteine Protease from Spirometra erinaceieuropaei Spargana. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030186