The Usefulness of Clinical-Practice-Based Laboratory Data in Facilitating the Diagnosis of Dengue Illness
Joint Authors
Chen, Rong-Fu
Liu, Jien-Wei
Lee, Ing-Kit
Yang, Kuender D.
Wang, Lin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Alertness to dengue and making a timely diagnosis is extremely important in the treatment of dengue and containment of dengue epidemics.
We evaluated the complementary role of clinical-practice-based laboratory data in facilitating suspicion/diagnosis of dengue.
One hundred overall dengue (57 dengue fever [DF] and 43 dengue hemorrhagic fever [DHF]) cases and another 100 nondengue cases (78 viral infections other than dengue, 6 bacterial sepsis, and 16 miscellaneous diseases) were analyzed.
We separately compared individual laboratory variables (platelet count [PC] , prothrombin time [PT], activated partial thromboplastin time [APTT], alanine aminotransferase [ALT], and aspartate aminotransferase [AST]) and varied combined variables of DF and/or DHF cases with the corresponding ones of nondengue cases.
The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) in the diagnosis of DF and/or DHF were measured based on these laboratory variables.
While trade-off between sensitivity and specificity, and/or suboptimal PPV/NPV was found at measurements using these variables, prolonged APTT + normal PT + PC < 100 × 109 cells/L had a favorable sensitivity, specificity, PPV, and NPV in diagnosis of DF and/or DHF.
In conclusion, these data suggested that prolonged APTT + normal PT + PC < 100 × 109 cells/L is useful in evaluating the likelihood of DF and/or DHF.
American Psychological Association (APA)
Liu, Jien-Wei& Lee, Ing-Kit& Wang, Lin& Chen, Rong-Fu& Yang, Kuender D.. 2013. The Usefulness of Clinical-Practice-Based Laboratory Data in Facilitating the Diagnosis of Dengue Illness. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030187
Modern Language Association (MLA)
Liu, Jien-Wei…[et al.]. The Usefulness of Clinical-Practice-Based Laboratory Data in Facilitating the Diagnosis of Dengue Illness. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030187
American Medical Association (AMA)
Liu, Jien-Wei& Lee, Ing-Kit& Wang, Lin& Chen, Rong-Fu& Yang, Kuender D.. The Usefulness of Clinical-Practice-Based Laboratory Data in Facilitating the Diagnosis of Dengue Illness. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030187